Design Space Approach in Optimization of Fluid Bed Granulation and Tablets Compression Process
Joint Authors
Mašić, Ivana
Djuriš, Jelena
Medarević, Djordje
Vasiljević, Ivana
Krstić, Marko
Ibrić, Svetlana
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-31
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Medicine
Information Technology and Computer Science
Abstract EN
The aim of this study was to optimize fluid bed granulation and tablets compression processes using design space approach.
Type of diluent, binder concentration, temperature during mixing, granulation and drying, spray rate, and atomization pressure were recognized as critical formulation and process parameters.
They were varied in the first set of experiments in order to estimate their influences on critical quality attributes, that is, granules characteristics (size distribution, flowability, bulk density, tapped density, Carr's index, Hausner's ratio, and moisture content) using Plackett-Burman experimental design.
Type of diluent and atomization pressure were selected as the most important parameters.
In the second set of experiments, design space for process parameters (atomization pressure and compression force) and its influence on tablets characteristics was developed.
Percent of paracetamol released and tablets hardness were determined as critical quality attributes.
Artificial neural networks (ANNs) were applied in order to determine design space.
ANNs models showed that atomization pressure influences mostly on the dissolution profile, whereas compression force affects mainly the tablets hardness.
Based on the obtained ANNs models, it is possible to predict tablet hardness and paracetamol release profile for any combination of analyzed factors.
American Psychological Association (APA)
Djuriš, Jelena& Medarević, Djordje& Krstić, Marko& Vasiljević, Ivana& Mašić, Ivana& Ibrić, Svetlana. 2012. Design Space Approach in Optimization of Fluid Bed Granulation and Tablets Compression Process. The Scientific World Journal،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-452743
Modern Language Association (MLA)
Djuriš, Jelena…[et al.]. Design Space Approach in Optimization of Fluid Bed Granulation and Tablets Compression Process. The Scientific World Journal No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-452743
American Medical Association (AMA)
Djuriš, Jelena& Medarević, Djordje& Krstić, Marko& Vasiljević, Ivana& Mašić, Ivana& Ibrić, Svetlana. Design Space Approach in Optimization of Fluid Bed Granulation and Tablets Compression Process. The Scientific World Journal. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-452743
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-452743