Pharmacokinetic Study of Perioperative Intravenous Ifosfamide
Joint Authors
Sugarbaker, Paul H.
Mahteme, Haile
Stuart, O. Anthony
Van der Speeten, Kurt
Source
International Journal of Surgical Oncology
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-21
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The use of cancer chemotherapy and hyperthermia as part of a surgical procedure in the management of patients with peritoneal carcinomatosis has gained prominence in recent years with selected patients showing benefit.
Patients with peritoneal surface malignancy following cancer resection were treated with intraperitoneal hyperthermic (41.5–42.5°C) cisplatin and doxorubicin combined with the infusion of systemic ifosfamide chemotherapy.
The concentrations of ifosfamide and 4-hydroxyifosfamide were determined in plasma, peritoneal fluid, urine, and when possible, within small tumor nodules less than 1 cm.
Plasma concentrations of ifosfamide exceeded peritoneal fluid levels of ifosfamide during the 90 minutes of chemotherapy infusion.
Both ifosfamide and 4-hydroxyifosfamide could be recovered from peritoneal tumor nodules throughout the 90 minutes of ifosfamide continuous infusion and exceeded plasma concentrations.
4-Hydroxyifosfamide within peritoneal surface cancer nodules suggested a favorable pharmacologic endpoint in the study of ifosfamide administered in the operating room.
American Psychological Association (APA)
Van der Speeten, Kurt& Stuart, O. Anthony& Mahteme, Haile& Sugarbaker, Paul H.. 2011. Pharmacokinetic Study of Perioperative Intravenous Ifosfamide. International Journal of Surgical Oncology،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-452744
Modern Language Association (MLA)
Van der Speeten, Kurt…[et al.]. Pharmacokinetic Study of Perioperative Intravenous Ifosfamide. International Journal of Surgical Oncology No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-452744
American Medical Association (AMA)
Van der Speeten, Kurt& Stuart, O. Anthony& Mahteme, Haile& Sugarbaker, Paul H.. Pharmacokinetic Study of Perioperative Intravenous Ifosfamide. International Journal of Surgical Oncology. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-452744
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-452744