Tumor-Induced Osteomalacia Caused by Primary Fibroblast Growth Factor 23 Secreting Neoplasm in Axial Skeleton : A Case Report
Joint Authors
Gandhi, Gunjan Y.
Wu, Kevin J.
Gupta, Vivek
Shoraka, Ali Reza
Shah, Aashish A.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-17
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
We report the case of a 66-year-old woman with tumor-induced osteomalacia (TIO) caused by fibroblast growth factor 23 (FGF-23) secreting mesenchymal tumor localized in a lumbar vertebra and review other cases localized to the axial skeleton.
She presented with nontraumatic low back pain and spontaneous bilateral femur fractures.
Laboratory testing was remarkable for low serum phosphorus, phosphaturia, and significantly elevated serum FGF-23 level.
Magnetic resonance imaging (MRI) of the lumbar spine showed a focal lesion in the L-4 vertebra which was hypermetabolic on positron emission tomography (PET) scan.
A computed tomography (CT) guided needle biopsy showed a low grade spindle cell neoplasm with positive FGF-23 mRNA expression by reverse transcriptase polymerase chain reaction (RT-PCR), confirming the diagnosis of a phosphaturic mesenchymal tumor mixed connective tissue variant (PMTMCT).
The patient elected to have surgery involving anterior resection of L-4 vertebra with subsequent normalization of serum phosphorus.
Including the present case, we identified 12 cases of neoplasms localized to spine causing TIO.
To our knowledge, this paper represents the first documented case of lumbar vertebra PMT causing TIO.
TIO is a rare metabolic bone disorder that carries a favorable prognosis.
When a lesion is identifiable, surgical intervention is typically curative.
American Psychological Association (APA)
Gandhi, Gunjan Y.& Shah, Aashish A.& Wu, Kevin J.& Gupta, Vivek& Shoraka, Ali Reza. 2012. Tumor-Induced Osteomalacia Caused by Primary Fibroblast Growth Factor 23 Secreting Neoplasm in Axial Skeleton : A Case Report. Case Reports in Endocrinology،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-452776
Modern Language Association (MLA)
Gandhi, Gunjan Y.…[et al.]. Tumor-Induced Osteomalacia Caused by Primary Fibroblast Growth Factor 23 Secreting Neoplasm in Axial Skeleton : A Case Report. Case Reports in Endocrinology No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-452776
American Medical Association (AMA)
Gandhi, Gunjan Y.& Shah, Aashish A.& Wu, Kevin J.& Gupta, Vivek& Shoraka, Ali Reza. Tumor-Induced Osteomalacia Caused by Primary Fibroblast Growth Factor 23 Secreting Neoplasm in Axial Skeleton : A Case Report. Case Reports in Endocrinology. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-452776
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-452776