The Role of Astrocytes in the Regulation of Synaptic Plasticity and Memory Formation
Joint Authors
Ota, Yusuke
Zanetti, Alexander T.
Hallock, Robert M.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-12-04
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Astrocytes regulate synaptic transmission and play a role in the formation of new memories, long-term potentiation (LTP), and functional synaptic plasticity.
Specifically, astroglial release of glutamate, ATP, and cytokines likely alters the survivability and functioning of newly formed connections.
Among these pathways, regulation of glutamate appears to be most directly related to the promotion of LTP, which is highly dependent on the synchronization of synaptic receptors through the regulation of excitatory postsynaptic potentials.
Moreover, regulation of postsynaptic glutamate receptors, particularly AMPA receptors, is dependent on signaling by ATP synthesized in astrocytes.
Finally, cytokine signaling is also implicated in regulating LTP, but is likely most important in plasticity following tissue damage.
Despite the role of these signaling factors in regulating LTP and functional plasticity, an integrative model of these factors has not yet been elucidated.
In this review, we seek to summarize the current body of evidence on astrocytic mechanisms for regulation of LTP and functional plasticity, and provide an integrative model of the processes.
American Psychological Association (APA)
Ota, Yusuke& Zanetti, Alexander T.& Hallock, Robert M.. 2013. The Role of Astrocytes in the Regulation of Synaptic Plasticity and Memory Formation. Neural Plasticity،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-452779
Modern Language Association (MLA)
Ota, Yusuke…[et al.]. The Role of Astrocytes in the Regulation of Synaptic Plasticity and Memory Formation. Neural Plasticity No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-452779
American Medical Association (AMA)
Ota, Yusuke& Zanetti, Alexander T.& Hallock, Robert M.. The Role of Astrocytes in the Regulation of Synaptic Plasticity and Memory Formation. Neural Plasticity. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-452779
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-452779