The Potential Use of Melatonin for Preventing Cisplatin Ototoxicity : An Insight for a Clinical Approach
Joint Authors
Ramos Venosa, Alessandra
Gusmão de Araujo, Juliana
Sampaio, André Luiz Lopes
Oliveira, Carlos Augusto Costa Pires De
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-18
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Cisplatin, one of the most effective and potent anticancer drugs, is used in the treatment of a wide variety of both pediatric and adult malignancies.
However, the chemotherapeutic use of cisplatin is limited by its serious side effects, such as nephrotoxicity and ototoxicity.
Ototoxicity produced by cisplatin is usually persistent, depending on the age of the patient, the cumulative number of doses, the number of chemotherapy cycles, the history of noise exposure, and deteriorating renal function.
The mechanism of the ototoxicity caused by cisplatin is based on the generation of reactive oxygen species, which interfere with the antioxidant protection of the organ of Corti.
Thus, protecting the cochlea with antioxidants ameliorates ototoxicity from cisplatin.
In this context, melatonin appears as a therapeutic option for preventing the ototoxic effects of cisplatin, since the research in the last decade has proven its ability to be both a direct free radical scavenger and indirect antioxidant.
In this sense, some of the evidence suggesting that melatonin is efficient for combating cisplatin-induced ototoxicity is summarized and discussed in this paper.
American Psychological Association (APA)
Gusmão de Araujo, Juliana& Sampaio, André Luiz Lopes& Ramos Venosa, Alessandra& Oliveira, Carlos Augusto Costa Pires De. 2014. The Potential Use of Melatonin for Preventing Cisplatin Ototoxicity : An Insight for a Clinical Approach. Advances in Otolaryngology،Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-452790
Modern Language Association (MLA)
Gusmão de Araujo, Juliana…[et al.]. The Potential Use of Melatonin for Preventing Cisplatin Ototoxicity : An Insight for a Clinical Approach. Advances in Otolaryngology No. 2014 (2014), pp.1-8.
https://search.emarefa.net/detail/BIM-452790
American Medical Association (AMA)
Gusmão de Araujo, Juliana& Sampaio, André Luiz Lopes& Ramos Venosa, Alessandra& Oliveira, Carlos Augusto Costa Pires De. The Potential Use of Melatonin for Preventing Cisplatin Ototoxicity : An Insight for a Clinical Approach. Advances in Otolaryngology. 2014. Vol. 2014, no. 2014, pp.1-8.
https://search.emarefa.net/detail/BIM-452790
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-452790