Antidiabetic Activity of Artemisia amygdalina Decne in Streptozotocin Induced Diabetic Rats
Joint Authors
Dar, Mohammad Younis
Akbar, Seema
Tantry, Mudasir A.
Ghazanfar, Khalid
Mubashir, Khan
Dar, Showkat Ahmad
Ganai, Bashir A.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-21
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Artemisia species have been extensively used for the management of diabetes in folklore medicine.
The current study was designed to investigate the antidiabetic and antihyperlipidemic effects of Artemisia amygdalina.
Petroleum ether, ethyl acetate, methanol, and hydroethanolic extracts of Artemisia amygdalina were tested for their antidiabetic potentials in diabetic rats.
The effect of extracts was observed by checking the biochemical, physiological, and histopathological parameters in diabetic rats.
The hydroethanolic and methanolic extracts each at doses of 250 and 500 mg/kg b.
w significantly reduced glucose levels in diabetic rats.
The other biochemical parameters like cholesterol, triglycerides, low density lipoproteins (LDL), serum creatinine, serum glutamate pyruvate transaminase (SGPT), serum glutamate oxaloacetate transaminase (SGOT), and alkaline phosphatise (ALP), were found to be reduced by the hydroethanolic and methanolic extracts.
The extracts also showed reduction in the feed and water consumption of diabetic rats when compared with the diabetic control.
The histopathological results of treated groups showed the regenerative/protective effect on β-cells of pancreas in diabetic rats.
The current study revealed the antidiabetic potential of Artemisia amygdalina being effective in hyperglycemia and that it can effectively protect against other metabolic aberrations caused by diabetes in rats, which seems to validate its therapeutic traditional use.
American Psychological Association (APA)
Ghazanfar, Khalid& Ganai, Bashir A.& Akbar, Seema& Mubashir, Khan& Dar, Showkat Ahmad& Dar, Mohammad Younis…[et al.]. 2014. Antidiabetic Activity of Artemisia amygdalina Decne in Streptozotocin Induced Diabetic Rats. BioMed Research International،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-452802
Modern Language Association (MLA)
Ghazanfar, Khalid…[et al.]. Antidiabetic Activity of Artemisia amygdalina Decne in Streptozotocin Induced Diabetic Rats. BioMed Research International No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-452802
American Medical Association (AMA)
Ghazanfar, Khalid& Ganai, Bashir A.& Akbar, Seema& Mubashir, Khan& Dar, Showkat Ahmad& Dar, Mohammad Younis…[et al.]. Antidiabetic Activity of Artemisia amygdalina Decne in Streptozotocin Induced Diabetic Rats. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-452802
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-452802