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Altered Responses to Cold Environment in Urocortin 1 and Corticotropin-Releasing Factor Deficient Mice
Joint Authors
Samra, Tareq A.
Datta, Nabanita S.
Abou-Samra, Abdul B.
Chaker, Bayan
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-05-27
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
We examined core body temperature (CBT) of urocortin 1 (UCN1) and corticotropin releasing factor (CRF) knockout (KO) mice exposed to 4°C for 2 h.
UCN1KO mice showed higher average CBT during cold exposure as compared to WT.
The CBT of male and female WT mice dropped significantly to 34.1 ± 2.4 and 34.9 ± 3.1 C at 4°C, respectively.
In contrast, the CBT of male and female UCN1KO mice dropped only slightly after 2 h at 4°C to 36.8 ± 0.7 and 38.1 ± 0.5 C, respectively.
WT female and male UCN1KO mice showed significant acclimatization to cold; however, female UCN1KO mice did not show such a significant acclimatization.
CRFKO mice showed a dramatic decline in CBT from 38.2 ± 0.4 at 22°C to 26.1 ± 9.8 at 4°C for 2 h.
The CRF/UCN1 double KO (dKO) mice dropped their CBT to 32.5 ± 4.0 after 2 h exposure to 4°C.
Dexamethasone treatment prevented the decline in CBT of the CRFKO and the dKO mice.
Taken together, the data suggest a novel role for UCN1 in thermoregulation.
The role of CRF is likely secondary to adrenal glucocorticoids, which have an important regulatory role on carbohydrate, fat, and protein metabolism.
American Psychological Association (APA)
Chaker, Bayan& Samra, Tareq A.& Datta, Nabanita S.& Abou-Samra, Abdul B.. 2013. Altered Responses to Cold Environment in Urocortin 1 and Corticotropin-Releasing Factor Deficient Mice. Physiology Journal،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-452813
Modern Language Association (MLA)
Chaker, Bayan…[et al.]. Altered Responses to Cold Environment in Urocortin 1 and Corticotropin-Releasing Factor Deficient Mice. Physiology Journal No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-452813
American Medical Association (AMA)
Chaker, Bayan& Samra, Tareq A.& Datta, Nabanita S.& Abou-Samra, Abdul B.. Altered Responses to Cold Environment in Urocortin 1 and Corticotropin-Releasing Factor Deficient Mice. Physiology Journal. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-452813
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-452813