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Preventive Effect of Pine Bark Extract (Flavangenol) on Metabolic Disease in Western Diet-Loaded Tsumura Suzuki Obese Diabetes Mice
Joint Authors
Takagaki, Kinya
Kosugi, Mitsutaka
Tokuhara, Daisuke
Miyamoto, Ken-ichi
Shimada, Tsutomu
Kamiya, Tomoyasu
Sameshima, Mayu
Aburada, Masaki
Tsubata, Masahito
Nagamine, Rika
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-03-17
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
It is known that the metabolic syndrome has a multi-factorial basis involving both genetic and environmental risk factors.
In this study, Tsumura Suzuki Obese Diabetes (TSOD) mice, a mouse model of multi-factorial, hereditary, obese type II diabetes, were given a Western diet (WTD) as an environmental factor to prepare a disease model (TSOD-WTD) and to investigate the preventive effects of Pine bark extract (Flavangenol) against obesity and various features of metabolic disease appearing in this animal model.
In contrast to control Tsumura Suzuki Non-obesity (TSNO) mice, TSOD mice were obese and suffered from other metabolic complications.
WTD-fed TSOD mice developed additional features such as hyperinsulinemia, abnormal glucose/lipid metabolism and fatty liver.
The treatment with Flavangenol had a suppressive effect on increase in body weight and accumulation of visceral and subcutaneous fat, and also showed preventive effects on symptoms related to insulin resistance, abnormal glucose/lipid metabolism and hypertension.
Flavangenol also increased the plasma concentration of adiponectin and decreased the plasma concentration of TNF-α.
We next investigated the effect of Flavangenol on absorption of meal-derived lipids.
Flavangenol suppressed absorption of neutral fat in an olive-oil-loading test (in vivo) and showed an inhibitory effect on pancreatic lipase (in vitro).
The above results suggest that Flavangenol has a preventive effect on severe metabolic disease due to multiple causes that involve both genetic and environmental risk factors.
The mechanism of action might involve a partial suppressive effect of meal-derived lipids on absorption.
American Psychological Association (APA)
Shimada, Tsutomu& Kosugi, Mitsutaka& Tokuhara, Daisuke& Tsubata, Masahito& Kamiya, Tomoyasu& Sameshima, Mayu…[et al.]. 2011. Preventive Effect of Pine Bark Extract (Flavangenol) on Metabolic Disease in Western Diet-Loaded Tsumura Suzuki Obese Diabetes Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-452829
Modern Language Association (MLA)
Shimada, Tsutomu…[et al.]. Preventive Effect of Pine Bark Extract (Flavangenol) on Metabolic Disease in Western Diet-Loaded Tsumura Suzuki Obese Diabetes Mice. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-452829
American Medical Association (AMA)
Shimada, Tsutomu& Kosugi, Mitsutaka& Tokuhara, Daisuke& Tsubata, Masahito& Kamiya, Tomoyasu& Sameshima, Mayu…[et al.]. Preventive Effect of Pine Bark Extract (Flavangenol) on Metabolic Disease in Western Diet-Loaded Tsumura Suzuki Obese Diabetes Mice. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-452829
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-452829