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Evaluation of the Antioxidant Activity and Antiproliferative Effect of the Jaboticaba (Myrciaria cauliflora) Seed Extracts in Oral Carcinoma Cells
Joint Authors
Yang, Ming Hui
Chen, Zong-Shiow
Tsai, Wan-Chi
Lin, Ching-Gong
Wang, Wen-Hung
Tyan, Yu Chang
Yuan, Shyng Shiou
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-18
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
It is becoming increasingly evident that certain phytochemicals possess cancer chemopreventive properties.
In this study, the antiproliferative activity of extracts from different parts of the jaboticaba (Myrciaria cauliflora) plant was evaluated for its effect on human oral carcinoma cell lines.
The cytotoxicities of various plant extract concentrations were examined and the 50% maximal inhibitory concentration (IC50) was determined.
Water extracts of jaboticaba seeds showed concentration-dependent antiproliferative effects.
Annexin V/propidium iodide positivity with active caspase-3 induction indicated that the treated cells underwent apoptosis.
Several important regulatory proteins (Bcl-2, Bcl-xL, Bid, and survivin) involved in apoptosis were also evaluated.
The antioxidant activity of jaboticaba was investigated using 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2′-azinobis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) assays, and the drug concentration eliciting 50% maximum stimulation (SC50) was determined.
The present findings suggest that water extracts of jaboticaba seeds exhibit an antiproliferative effect against oral cancer cells by inducing apoptosis through downregulating survivin expression and thereby activating caspase-mediated Bid cleavage.
American Psychological Association (APA)
Wang, Wen-Hung& Tyan, Yu Chang& Chen, Zong-Shiow& Lin, Ching-Gong& Yang, Ming Hui& Yuan, Shyng Shiou…[et al.]. 2014. Evaluation of the Antioxidant Activity and Antiproliferative Effect of the Jaboticaba (Myrciaria cauliflora) Seed Extracts in Oral Carcinoma Cells. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-452835
Modern Language Association (MLA)
Wang, Wen-Hung…[et al.]. Evaluation of the Antioxidant Activity and Antiproliferative Effect of the Jaboticaba (Myrciaria cauliflora) Seed Extracts in Oral Carcinoma Cells. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-452835
American Medical Association (AMA)
Wang, Wen-Hung& Tyan, Yu Chang& Chen, Zong-Shiow& Lin, Ching-Gong& Yang, Ming Hui& Yuan, Shyng Shiou…[et al.]. Evaluation of the Antioxidant Activity and Antiproliferative Effect of the Jaboticaba (Myrciaria cauliflora) Seed Extracts in Oral Carcinoma Cells. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-452835
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-452835