Structural Features and Transcriptional Activity of Chicken PPARs (α, β, and γ)
Joint Authors
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-01-03
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
While an understanding of lipid metabolism in chickens is critical for a further improvement of food production, there are few studies concerning differences in lipid metabolism mechanisms between chickens and other species at a molecular level.
Chickens have three PPAR gene subtypes (α, β, and γ) that function differently from those present in humans and mice.
The chicken PPAR-gamma (cPPARγ) gene is shorter than that in humans and lacks a γ2 isoform.
Moreover, in serum-free media, cPPARγ shows high transcriptional activity without exogenous ligands.
Luciferase reporter assays were used to examine the effect of sera on cPPAR transcriptional activities and showed that adult bovine serum and chicken serum highly activate cPPARα and β functions.
Moreover, we found that bezafibrate induces the transactivation function of cPPARβ, but not human PPARδ (human PPARβ ortholog).
This ligand selectivity relies on one amino acid residue (chicken: Val419, human: Met444).
These results show the possibilities for unique functions of cPPARs on chicken-specific lipid glucose metabolism.
As such, a better understanding of the molecular mechanisms of lipid metabolism in chickens could result in higher productivity for the poultry industry.
American Psychological Association (APA)
Takada, Ichiro& Kobayashi, Mime. 2013. Structural Features and Transcriptional Activity of Chicken PPARs (α, β, and γ). PPAR Research،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-452870
Modern Language Association (MLA)
Takada, Ichiro& Kobayashi, Mime. Structural Features and Transcriptional Activity of Chicken PPARs (α, β, and γ). PPAR Research No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-452870
American Medical Association (AMA)
Takada, Ichiro& Kobayashi, Mime. Structural Features and Transcriptional Activity of Chicken PPARs (α, β, and γ). PPAR Research. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-452870
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-452870