Extra Copies of der(21)t(12;21) plus Deletion of ETV6 Gene due to dic(12;18) in B-Cell Precursor ALL with Poor Outcome
Joint Authors
Cornélio, Maria Teresa Marquim Nogueira
Mkrtchyan, Hasmik
Muniz, Maria Tereza Cartaxo
Soares-Ventura, Eliane Maria
Liehr, Thomas
Santos, Neide
Hernandes, Marina Araújo Fonzar
Silva, Maria Luiza Macedo
Marques-Salles, Terezinha de Jesus
Leite, Edinalva Pereira
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-25
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
Acute lymphoblastic leukemia (ALL), CD10+ B-cell precursor, represents the most frequent type of childhood ALL from 3 to 6 years of age.
The t(12;21)(p13;q22) occurs in 25% of cases of B-cell precursor ALL, it is rare in children less than 24 months and have been related to good prognosis.
Some relapse cases and unfavorable prognosis in ALL CD10+ are associated with t(12;21) bearing additional aberrations as extra copies of chromosome 21 and ETV6 gene loss.
This report describes the case of a 15 month-year old girl, who displayed a karyotype with addition on chromosome 12p plus trisomy 10 and tetrasomy of chromosome 21.
Molecular cytogenetic studies revealed two extra copies of the der(21) t(12;21), trisomy 10 and deletion of the second ETV6 gene due to the dic(12;18).
These findings show the great importance of molecular cytogenetic studies to clarify complex karyotypes, to define prognostic, to carry out risk group stratification and to support correctly disease treatment in childhood acute lymphoblastic leukemia.
American Psychological Association (APA)
Hernandes, Marina Araújo Fonzar& Marques-Salles, Terezinha de Jesus& Mkrtchyan, Hasmik& Soares-Ventura, Eliane Maria& Leite, Edinalva Pereira& Muniz, Maria Tereza Cartaxo…[et al.]. 2012. Extra Copies of der(21)t(12;21) plus Deletion of ETV6 Gene due to dic(12;18) in B-Cell Precursor ALL with Poor Outcome. Case Reports in Genetics،Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-452896
Modern Language Association (MLA)
Hernandes, Marina Araújo Fonzar…[et al.]. Extra Copies of der(21)t(12;21) plus Deletion of ETV6 Gene due to dic(12;18) in B-Cell Precursor ALL with Poor Outcome. Case Reports in Genetics No. 2012 (2012), pp.1-4.
https://search.emarefa.net/detail/BIM-452896
American Medical Association (AMA)
Hernandes, Marina Araújo Fonzar& Marques-Salles, Terezinha de Jesus& Mkrtchyan, Hasmik& Soares-Ventura, Eliane Maria& Leite, Edinalva Pereira& Muniz, Maria Tereza Cartaxo…[et al.]. Extra Copies of der(21)t(12;21) plus Deletion of ETV6 Gene due to dic(12;18) in B-Cell Precursor ALL with Poor Outcome. Case Reports in Genetics. 2012. Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-452896
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-452896