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Production of Nitric Oxide and Expression of Inducible Nitric Oxide Synthase in Ovarian Cystic Tumors
Source
Issue
Vol. 2008, Issue 2008 (31 Dec. 2008), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-01-05
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Tumor sections from nonneoplastic (n=15), benign (n=28), and malignant ovarian tumors (n=20) were obtained from 63 women.
Immunohistochemistry of the tumor sections demonstrated that inducible nitric oxide synthase (iNOS) expression was increased in ovarian cancer samples compared to nonneoplastic or benign tumor samples.
Using the Griess method, nitric oxide (NO) metabolite levels were also found to be elevated in malignant tumor samples compared to benign tumor samples (P<.05).
For stage I ovarian cancer, intracystic NO levels >80 μM were more frequent than NO levels <80 μM, and iNOS expression in well-differentiated carcinomas was greater than in moderately/poorly differentiated carcinomas (P<.05).
These data suggest an important role for NO in ovarian carcinogenesis.
American Psychological Association (APA)
2009. Production of Nitric Oxide and Expression of Inducible Nitric Oxide Synthase in Ovarian Cystic Tumors. Mediators of Inflammation،Vol. 2008, no. 2008, pp.1-7.
https://search.emarefa.net/detail/BIM-452904
Modern Language Association (MLA)
Production of Nitric Oxide and Expression of Inducible Nitric Oxide Synthase in Ovarian Cystic Tumors. Mediators of Inflammation No. 2008 (2008), pp.1-7.
https://search.emarefa.net/detail/BIM-452904
American Medical Association (AMA)
Production of Nitric Oxide and Expression of Inducible Nitric Oxide Synthase in Ovarian Cystic Tumors. Mediators of Inflammation. 2009. Vol. 2008, no. 2008, pp.1-7.
https://search.emarefa.net/detail/BIM-452904
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-452904