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Helicobacter pylori Eradication Therapy : Current Availabilities
Joint Authors
Pescarin, M.
Gasparetto, Marco
Guariso, Graziella
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-29
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
Though Helicobacter pylori (HP) infections have progressively declined throughout most of the industrialized countries, a gradual increase in failure of HP eradication treatments is observed.
Aim.
To critically review evidence on the efficacy of the therapeutic availabilities for HP eradication, as yet.
Methods.
A selection of Clinical Trials, Systematic Reviews and Meta-analyses within the time period 2010–2012, was performed through a Medline search.
Previous references were included when basically supporting the first selection.
Results.
An increasing rise in HP resistance rates for antimicrobial agents is currently observed.
Further causes of HP treatment failure include polymorphisms of the CYP 2C19, an increased body mass index (BMI), smoking, poor compliance and re-infections.
Alternative recent approaches to standard triple therapy have been attempted to increase the eradication rate, including bismuth-containing quadruple therapy, non-bismuth containing quadruple therapy, sequential therapy and levofloxacin-containing regimens.
Conclusions.
The main current aims should be the maintenance of a high eradication rate (>85%) of HP and the prevention of any increase in antimicrobial resistance.
In the next future, the perspective of a tailored therapy could optimize eradication regimens within the different countries.
American Psychological Association (APA)
Gasparetto, Marco& Pescarin, M.& Guariso, Graziella. 2012. Helicobacter pylori Eradication Therapy : Current Availabilities. ISRN Gastroenterology،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-452910
Modern Language Association (MLA)
Gasparetto, Marco…[et al.]. Helicobacter pylori Eradication Therapy : Current Availabilities. ISRN Gastroenterology No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-452910
American Medical Association (AMA)
Gasparetto, Marco& Pescarin, M.& Guariso, Graziella. Helicobacter pylori Eradication Therapy : Current Availabilities. ISRN Gastroenterology. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-452910
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-452910