Complex Variant t(9;22) Chromosome Translocations in Five Cases of Chronic Myeloid Leukemia
Joint Authors
Fuster, Oscar
Collado, Rosa
Cervera, José
Sanz, Miguel A.
Martínez, Jesús
Bolufer, Pascual
Valencia, Ana
Barragán, Eva
Such, Esperanza
Source
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-07-28
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
The Philadelphia (Ph1) chromosome arising from the reciprocal t(9;22) translocation is found in more than 90% of chronic myeloid leukemia (CML) patients and results in the formation of the chimeric fusion gene BCR-ABL.
However, a small proportion of patients with CML have simple or complex variants of this translocation, involving various breakpoints in addition to 9q34 and 22q11.
We report five CML cases carrying variant Ph translocations involving both chromosomes 9 and 22 as well as chromosomes 3, 5, 7, 8, or 10.
G-banding showed a reciprocal three-way translocation involving 3q21, 5q31, 7q32, 8q24, and 10q22 bands.
BCR-ABL fusion signal on der(22) was found in all of the cases by FISH.
American Psychological Association (APA)
Valencia, Ana& Cervera, José& Such, Esperanza& Barragán, Eva& Bolufer, Pascual& Fuster, Oscar…[et al.]. 2009. Complex Variant t(9;22) Chromosome Translocations in Five Cases of Chronic Myeloid Leukemia. Advances in Hematology،Vol. 2009, no. 2009, pp.1-4.
https://search.emarefa.net/detail/BIM-452953
Modern Language Association (MLA)
Valencia, Ana…[et al.]. Complex Variant t(9;22) Chromosome Translocations in Five Cases of Chronic Myeloid Leukemia. Advances in Hematology No. 2009 (2009), pp.1-4.
https://search.emarefa.net/detail/BIM-452953
American Medical Association (AMA)
Valencia, Ana& Cervera, José& Such, Esperanza& Barragán, Eva& Bolufer, Pascual& Fuster, Oscar…[et al.]. Complex Variant t(9;22) Chromosome Translocations in Five Cases of Chronic Myeloid Leukemia. Advances in Hematology. 2009. Vol. 2009, no. 2009, pp.1-4.
https://search.emarefa.net/detail/BIM-452953
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-452953
