Striatal Hypodensities, Not White Matter Hypodensities on CT, Are Associated with Late-Onset Depression in Alzheimer's Disease
Joint Authors
Go, John L.
Mack, Wendy J.
Gatz, Margaret
Brommelhoff, Jessica A.
Spann, Bryan M.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-21
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Pharmacy, Health & Medical Sciences
Abstract EN
This study examined whether there were neuroanatomical differences evident on CT scans of individuals with dementia who differed on depression history.
Neuroanatomical variables consisted of visual ratings of frontal lobe deep white matter, subcortical white matter, and subcortical gray matter hypodensities in the CT scans of 182 individuals from the Study of Dementia in Swedish Twins who were diagnosed with dementia and had information on depression history.
Compared to individuals with Alzheimer's disease and no depression, individuals with Alzheimer's disease and late-onset depression (first depressive episode at age 60 or over) had a greater number of striatal hypodensities (gray matter hypodensities in the caudate nucleus and lentiform nucleus).
There were no significant differences in frontal lobe deep white matter or subcortical white matter.
These findings suggest that late-onset depression may be a process that is distinct from the neurodegenerative changes caused by Alzheimer's disease.
American Psychological Association (APA)
Brommelhoff, Jessica A.& Spann, Bryan M.& Go, John L.& Mack, Wendy J.& Gatz, Margaret. 2011. Striatal Hypodensities, Not White Matter Hypodensities on CT, Are Associated with Late-Onset Depression in Alzheimer's Disease. Journal of Aging Research،Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-452960
Modern Language Association (MLA)
Brommelhoff, Jessica A.…[et al.]. Striatal Hypodensities, Not White Matter Hypodensities on CT, Are Associated with Late-Onset Depression in Alzheimer's Disease. Journal of Aging Research No. 2011 (2011), pp.1-11.
https://search.emarefa.net/detail/BIM-452960
American Medical Association (AMA)
Brommelhoff, Jessica A.& Spann, Bryan M.& Go, John L.& Mack, Wendy J.& Gatz, Margaret. Striatal Hypodensities, Not White Matter Hypodensities on CT, Are Associated with Late-Onset Depression in Alzheimer's Disease. Journal of Aging Research. 2011. Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-452960
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-452960