Neurodegeneration in Alzheimer Disease : Role of Amyloid Precursor Protein and Presenilin 1 Intracellular Signaling
Joint Authors
Corsaro, Alessandro
Porcile, Carola
Thellung, Stefano
Villa, Valentina
Nizzari, Mario
Florio, Tullio
Russo, Claudio
Pagano, Aldo
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-08
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Pharmacy, Health & Medical Sciences
Medicine
Abstract EN
Alzheimer disease (AD) is a heterogeneous neurodegenerative disorder characterized by (1) progressive loss of synapses and neurons, (2) intracellular neurofibrillary tangles, composed of hyperphosphorylated Tau protein, and (3) amyloid plaques.
Genetically, AD is linked to mutations in few proteins amyloid precursor protein (APP) and presenilin 1 and 2 (PS1 and PS2).
The molecular mechanisms underlying neurodegeneration in AD as well as the physiological function of APP are not yet known.
A recent theory has proposed that APP and PS1 modulate intracellular signals to induce cell-cycle abnormalities responsible for neuronal death and possibly amyloid deposition.
This hypothesis is supported by the presence of a complex network of proteins, clearly involved in the regulation of signal transduction mechanisms that interact with both APP and PS1.
In this review we discuss the significance of novel finding related to cell-signaling events modulated by APP and PS1 in the development of neurodegeneration.
American Psychological Association (APA)
Nizzari, Mario& Thellung, Stefano& Corsaro, Alessandro& Villa, Valentina& Pagano, Aldo& Porcile, Carola…[et al.]. 2012. Neurodegeneration in Alzheimer Disease : Role of Amyloid Precursor Protein and Presenilin 1 Intracellular Signaling. Journal of Toxicology،Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-452969
Modern Language Association (MLA)
Nizzari, Mario…[et al.]. Neurodegeneration in Alzheimer Disease : Role of Amyloid Precursor Protein and Presenilin 1 Intracellular Signaling. Journal of Toxicology No. 2012 (2012), pp.1-13.
https://search.emarefa.net/detail/BIM-452969
American Medical Association (AMA)
Nizzari, Mario& Thellung, Stefano& Corsaro, Alessandro& Villa, Valentina& Pagano, Aldo& Porcile, Carola…[et al.]. Neurodegeneration in Alzheimer Disease : Role of Amyloid Precursor Protein and Presenilin 1 Intracellular Signaling. Journal of Toxicology. 2012. Vol. 2012, no. 2012, pp.1-13.
https://search.emarefa.net/detail/BIM-452969
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-452969