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Vascular Dysfunction as Target Organ Damage in Animal Models of Hypertension
Joint Authors
Neves, Mario Fritsch
Kasal, Daniel Arthur B.
Medeiros, Fernanda
Cunha, Ana Rosa
Source
International Journal of Hypertension
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-14
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Endothelial dysfunction is one of the main characteristics of chronic hypertension and it is characterized by impaired nitric oxide (NO) bioactivity determined by increased levels of reactive oxygen species.
Endothelial function is usually evaluated by measuring the vasodilation induced by the local NO production stimulated by external mechanical or pharmacological agent.
These vascular reactivity tests may be carried out in different models of experimental hypertension such as NO-deficient rats, spontaneously hypertensive rats, salt-sensitive rats, and many others.
Wire myograph and pressurized myograph are the principal methods used for vascular studies.
Usually, increasing concentrations of the vasodilator acetylcholine are added in cumulative manner to perform endothelium-dependent concentration-response curves.
Analysis of vascular mechanics is relevant to identify arterial stiffness.
Both endothelial dysfunction and vascular stiffness have been shown to be associated with increased cardiovascular risk.
American Psychological Association (APA)
Neves, Mario Fritsch& Kasal, Daniel Arthur B.& Cunha, Ana Rosa& Medeiros, Fernanda. 2012. Vascular Dysfunction as Target Organ Damage in Animal Models of Hypertension. International Journal of Hypertension،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-452990
Modern Language Association (MLA)
Neves, Mario Fritsch…[et al.]. Vascular Dysfunction as Target Organ Damage in Animal Models of Hypertension. International Journal of Hypertension No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-452990
American Medical Association (AMA)
Neves, Mario Fritsch& Kasal, Daniel Arthur B.& Cunha, Ana Rosa& Medeiros, Fernanda. Vascular Dysfunction as Target Organ Damage in Animal Models of Hypertension. International Journal of Hypertension. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-452990
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-452990