Cryptolepine-Induced Cell Death of Leishmania donovani Promastigotes Is Augmented by Inhibition of Autophagy
Joint Authors
Sengupta, Souvik
BoseDasgupta, Somdeb
Chowdhury, Sayan
Majumder, Hemanta K.
Wright, Colin W.
Source
Molecular Biology International
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-03-03
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Leishmania donovani are the causative agents of visceral leishmaniasis worldwide.
Lack of vaccines and emergence of drug resistance warrants the need for improved drug therapy and newer therapeutic intervention strategies against leishmaniasis.
In the present study, we have investigated the effect of the natural indoloquinoline alkaloid cryptolepine on L.
donovani AG83 promastigotes.
Our results show that cryptolepine induces cellular dysfunction in L.
donovani promastigotes, which leads to the death of this unicellular parasite.
Interestingly, our study suggest that cryptolepine-induced cell death of L.
donovani is counteracted by initial autophagic features elicited by the cells.
For the first time, we show that autophagy serves as a survival mechanism in response to cryptolepine treatment in L.
donovani promastigotes and inhibition of autophagy causes an early increase in the amount of cell death.
This study can be exploited for designing better drugs and better therapeutic strategies against leishmaniasis in future.
American Psychological Association (APA)
Sengupta, Souvik& Chowdhury, Sayan& BoseDasgupta, Somdeb& Wright, Colin W.& Majumder, Hemanta K.. 2011. Cryptolepine-Induced Cell Death of Leishmania donovani Promastigotes Is Augmented by Inhibition of Autophagy. Molecular Biology International،Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-453015
Modern Language Association (MLA)
Sengupta, Souvik…[et al.]. Cryptolepine-Induced Cell Death of Leishmania donovani Promastigotes Is Augmented by Inhibition of Autophagy. Molecular Biology International No. 2011 (2011), pp.1-12.
https://search.emarefa.net/detail/BIM-453015
American Medical Association (AMA)
Sengupta, Souvik& Chowdhury, Sayan& BoseDasgupta, Somdeb& Wright, Colin W.& Majumder, Hemanta K.. Cryptolepine-Induced Cell Death of Leishmania donovani Promastigotes Is Augmented by Inhibition of Autophagy. Molecular Biology International. 2011. Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-453015
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-453015