Relationships of Adiponectin with Markers of Systemic Inflammation and Insulin Resistance in Infants Undergoing Open Cardiac Surgery
Joint Authors
Yang, Ting
Gu, Chunhu
Yi, Dinghua
Sun, Guocheng
Cao, Yukun
Yu, Shiqiang
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-10
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
Insulin resistance and systemic inflammation frequently occur in infants undergoing cardiac surgery with cardiopulmonary bypass, while adiponectin has been demonstrated to have insulin-sensitizing and anti-inflammatory properties in obesity and type 2 diabetes mellitus.
In this prospective study, we aimed to investigate the association of adiponectin with insulin resistance and inflammatory mediators in infants undergoing cardiac surgery with cardiopulmonary bypass.
Methods and Results.
From sixty infants undergoing open cardiac surgery, blood samples were taken before anesthesia, at the initiation of cardiopulmonary bypass and at 0, 6, 12, 24, and 48 hours after the termination of cardiopulmonary bypass.
Plasma interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), and adiponectin levels were assessed in blood samples.
Insulin resistance was measured by assessment of the insulin requirement to maintain euglycaemia and repeated measurements of an insulin glycaemic index.
Insulin glycaemic index, IL-6, and TNF-α increased up to 3–8-fold 6 h after the operation.
Adiponectin is negatively correlated with markers of systemic inflammation 6 h after CPB.
Conclusions.
Although the level of serum adiponectin decreased significantly, there was a significant inverse association of adiponectin with markers of systemic inflammation and insulin resistance in infants undergoing open cardiac surgery.
American Psychological Association (APA)
Cao, Yukun& Yang, Ting& Yu, Shiqiang& Sun, Guocheng& Gu, Chunhu& Yi, Dinghua. 2013. Relationships of Adiponectin with Markers of Systemic Inflammation and Insulin Resistance in Infants Undergoing Open Cardiac Surgery. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-453027
Modern Language Association (MLA)
Cao, Yukun…[et al.]. Relationships of Adiponectin with Markers of Systemic Inflammation and Insulin Resistance in Infants Undergoing Open Cardiac Surgery. Mediators of Inflammation No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-453027
American Medical Association (AMA)
Cao, Yukun& Yang, Ting& Yu, Shiqiang& Sun, Guocheng& Gu, Chunhu& Yi, Dinghua. Relationships of Adiponectin with Markers of Systemic Inflammation and Insulin Resistance in Infants Undergoing Open Cardiac Surgery. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-453027
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-453027