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Suppressive Effects of D-Glucosamine on the 5-HT Sensitive Nociceptive Units in the Rat Tooth Pulpal Nerve
Joint Authors
Hayashi, Yoshihiko
Yamashita, Hiromi
Toda, Kazuo
Kaida, Kei
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-10
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
It is well known that D-glucosamine hydrochloride (DGL) has a variety of biological activities and is regarded as a nutritional supplement effective in improving various disorders, including osteoarthritis and atherosclerosis.
Although it has been reported that DGL has a significant pain relief effect in treating osteoarthritis, little is known about the characteristics of the effects of this compound on dental pain.
The present study was undertaken to evaluate the applicability of DGL as a medicament to control pulpalgia.
Using an in vitro rat mandible-inferior alveolar nerve preparation (jaw-nerve preparation), we evaluated the effects of DGL on 5-hydroxytryptamine (5-HT) sensitive nociceptive responses in the tooth pulpal nerve.
5-HT-induced nociceptive responses were fairly suppressed by direct application of DGL, suggesting that DGL have a pain relief effect on patients with dental pain.
American Psychological Association (APA)
Kaida, Kei& Yamashita, Hiromi& Toda, Kazuo& Hayashi, Yoshihiko. 2014. Suppressive Effects of D-Glucosamine on the 5-HT Sensitive Nociceptive Units in the Rat Tooth Pulpal Nerve. BioMed Research International،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-453034
Modern Language Association (MLA)
Kaida, Kei…[et al.]. Suppressive Effects of D-Glucosamine on the 5-HT Sensitive Nociceptive Units in the Rat Tooth Pulpal Nerve. BioMed Research International No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-453034
American Medical Association (AMA)
Kaida, Kei& Yamashita, Hiromi& Toda, Kazuo& Hayashi, Yoshihiko. Suppressive Effects of D-Glucosamine on the 5-HT Sensitive Nociceptive Units in the Rat Tooth Pulpal Nerve. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-453034
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-453034