The Emerging Roles of Thyroglobulin
Joint Authors
Hiroi, Naoki
Ishido, Yuko
Suzuki, Koichi
Luo, Yuqian
Ishii, Norihisa
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-09
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Thyroglobulin (Tg), the most important and abundant protein in thyroid follicles, is well known for its essential role in thyroid hormone synthesis.
In addition to its conventional role as the precursor of thyroid hormones, we have uncovered a novel function of Tg as an endogenous regulator of follicular function over the past decade.
The newly discovered negative feedback effect of Tg on follicular function observed in the rat and human thyroid provides an alternative explanation for the observation of follicle heterogeneity.
Given the essential role of the regulatory effects of Tg, we consider that dysregulation of normal Tg function is associated with multiple human thyroid diseases including autoimmune thyroid disease and thyroid cancer.
Additionally, extrathyroid Tg may serve a regulatory function in other organs.
Further exploration of Tg action, especially at the molecular level, is needed to obtain a better understanding of both the physiological and pathological roles of Tg.
American Psychological Association (APA)
Luo, Yuqian& Ishido, Yuko& Hiroi, Naoki& Ishii, Norihisa& Suzuki, Koichi. 2014. The Emerging Roles of Thyroglobulin. Advances in Endocrinology،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-453048
Modern Language Association (MLA)
Luo, Yuqian…[et al.]. The Emerging Roles of Thyroglobulin. Advances in Endocrinology No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-453048
American Medical Association (AMA)
Luo, Yuqian& Ishido, Yuko& Hiroi, Naoki& Ishii, Norihisa& Suzuki, Koichi. The Emerging Roles of Thyroglobulin. Advances in Endocrinology. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-453048
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-453048