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Evaluation of Cytotoxicity and Genotoxicity of Inula viscosa Leaf Extracts with Allium Test
Joint Authors
Aşkin Çelik, Tülay
Aslantürk, Özlem Sultan
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-06-23
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
I.
viscosa has been used for years in folk medicine for its anti-inflammatory, antipyretic, antiseptic, and paper antiphlogistic activities.
In this study, cytotoxic and genotoxic effects of I.
viscosa leaf extracts on the root meristem cells of Allium cepa have been examined.
Onion bulbs were exposed to 2.5 mg/ml, 5 mg/ml, and 10 mg/ml concentrations of the extracts for macroscopic and microscopic analysis.
Tap water has been used as a negative control and Ethyl methanesulfonate (EMS) (2⋅10−2 M) has been used as a positive control.
The test concentrations have been determined according to doses which are recommended for use in alternative medicine.
There has been statistically significant (P<.05) inhibition of root growth depending on concentration by the extracts when compared with the control groups.
All the tested extracts have been observed to have cytotoxic effects on cell division in A.
cepa.
I.
viscosa leaf extract induces the total number of chromosomal aberrations and micronuclei (MNC) formations in A.
cepa root tip cells significantly when compared with control groups.
Also, this paper shows for the first time the induction of cell death, ghost cells, cells with membrane damage, and binucleated cells by extract treatment.
These results suggest the cytotoxic and genotoxic effects of the I.
viscosa leaf extracts on A.
cepa.
American Psychological Association (APA)
Aşkin Çelik, Tülay& Aslantürk, Özlem Sultan. 2010. Evaluation of Cytotoxicity and Genotoxicity of Inula viscosa Leaf Extracts with Allium Test. Journal of Biomedicine and Biotechnology،Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-453057
Modern Language Association (MLA)
Aşkin Çelik, Tülay& Aslantürk, Özlem Sultan. Evaluation of Cytotoxicity and Genotoxicity of Inula viscosa Leaf Extracts with Allium Test. Journal of Biomedicine and Biotechnology No. 2010 (2010), pp.1-8.
https://search.emarefa.net/detail/BIM-453057
American Medical Association (AMA)
Aşkin Çelik, Tülay& Aslantürk, Özlem Sultan. Evaluation of Cytotoxicity and Genotoxicity of Inula viscosa Leaf Extracts with Allium Test. Journal of Biomedicine and Biotechnology. 2010. Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-453057
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-453057