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The Role of Helicobacter pylori and NSAIDs in the Pathogenesis of Uncomplicated Duodenal Ulcer
Joint Authors
Cekin, Yesim
Sezer, Cem
Taskoparan, Muharrem
Cekin, Ayhan Hilmi
Pehlivan, Fatma Seher
Cayırcı, Mine
Duman, Adil
Can, Hasan
Yolcular, Basak Oguz
Source
Gastroenterology Research and Practice
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-09-25
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background/Aim.
To identify the etiological role of Helicobacter pylori (Hp) and nonsteroidal anti-inflammatory drugs (NSAIDs) in endoscopically diagnosed duodenal ulcers (DUs).
Methods.
Patients undergoing esophagogastroduodenoscopy in two major hospitals in Antalya and Adiyaman were included in this study and assigned as duodenal ulcer (n=152; median age: 41.0 (16–71) years; 58.6% males) or control group (n=70; median age: 41.0 (18–68) years; 57.1% males).
Patient demographics, risk factors, and NSAID/acetylsalicylic acid (ASA) use were recorded.
Results.
HP was more commonly located in the corpus (75.0 versus 50.0%; odds ratio [OR] = 3.00; 95% confidence interval [CI]: 1.66–5.44; P<0.001), incisura (75.7 versus 60.0%; OR=2.07; 95% CI: 1.13–3.79; P=0.017), and antrum (80.3 versus 60.0%; OR=2.71; 95% CI: 1.45–5.05; P=0.001) among DU patients than controls.
Hp positivity was 84.9% while Hp was negative in 15.1% of patients including those accompanied with NSAID and/or ASA use (9.2%), and those were negative for all three etiological factors (5.9%).
Conclusion.
Our findings indicate the substantial role of Hp in the pathogenesis of DU disease as identified in 84.9% of DU patients compatible with the background prevalence of 61.4% among age-matched control subjects.
Hp was the single causative factor in 44.1% of our patients, while NSAID/ASA exposure was in 9.2%.
American Psychological Association (APA)
Cekin, Ayhan Hilmi& Taskoparan, Muharrem& Duman, Adil& Sezer, Cem& Cekin, Yesim& Yolcular, Basak Oguz…[et al.]. 2012. The Role of Helicobacter pylori and NSAIDs in the Pathogenesis of Uncomplicated Duodenal Ulcer. Gastroenterology Research and Practice،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-453070
Modern Language Association (MLA)
Cekin, Ayhan Hilmi…[et al.]. The Role of Helicobacter pylori and NSAIDs in the Pathogenesis of Uncomplicated Duodenal Ulcer. Gastroenterology Research and Practice No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-453070
American Medical Association (AMA)
Cekin, Ayhan Hilmi& Taskoparan, Muharrem& Duman, Adil& Sezer, Cem& Cekin, Yesim& Yolcular, Basak Oguz…[et al.]. The Role of Helicobacter pylori and NSAIDs in the Pathogenesis of Uncomplicated Duodenal Ulcer. Gastroenterology Research and Practice. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-453070
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-453070