Risk of Cardiovascular Diseases in Diabetes Mellitus and Serum Concentration of Asymmetrical Dimethylarginine
Joint Authors
Karnik, Aarti
Bhutey, Anil
Jawalekar, Seema L.
Source
Biochemistry Research International
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-26
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Introduction.
Asymmetric dimethylarginine (ADMA) is a nonselective nitric oxide (NO) synthase inhibitor associated with cardiovascular and metabolic disorders.
ADMA plays an important role in the regulation of vascular tone by acting as an endogenous inhibitor of NO synthesis.
Objectives.
This study aimed to investigate ADMA with respect to diabetes and its clinical relevance as an independent predictor of CAD (Coronary Artery Disease).
Methodology.
The present case control study includes two hundred and forty patients selected randomly.
Serum ADMA was analyzed by using enzyme immunoassay for the quantitative determination of endogenous ADMA, and serum nitric oxide was estimated by the method of Cortes.
Results.
Elevated NO level levels was a strong predictor and significantly (t: 9.86, P<0.001) associated with occurrence of CAD.
Increased ADMA level was found to be another strong predictor and associated significantly (t: 8.02, P<0.001) with CAD.
On intra group analysis, the relationship between ADMA and NO in diseased group, is significant negative correlation (r=-0.743).
P (0.001) was found between ADMA and NO.
Conclusion.
ADMA level was found to be one of the strong predictors for CAD.
ADMA is an emerging independent risk marker for future CVD (cardiovascular disease) events.
American Psychological Association (APA)
Jawalekar, Seema L.& Karnik, Aarti& Bhutey, Anil. 2013. Risk of Cardiovascular Diseases in Diabetes Mellitus and Serum Concentration of Asymmetrical Dimethylarginine. Biochemistry Research International،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-453080
Modern Language Association (MLA)
Jawalekar, Seema L.…[et al.]. Risk of Cardiovascular Diseases in Diabetes Mellitus and Serum Concentration of Asymmetrical Dimethylarginine. Biochemistry Research International No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-453080
American Medical Association (AMA)
Jawalekar, Seema L.& Karnik, Aarti& Bhutey, Anil. Risk of Cardiovascular Diseases in Diabetes Mellitus and Serum Concentration of Asymmetrical Dimethylarginine. Biochemistry Research International. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-453080
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-453080