Primary Biliary Cirrhosis : Family Stories
Joint Authors
Bogdanos, Dimitrios P.
Kriese, Stephen
Cholongitas, Evangelos
Smyk, Daniel S.
Rigopoulou, Eirini I.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-05-05
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Primary biliary cirrhosis (PBC) is a chronic immune-mediated cholestatic liver disease of unknown aetiology which affects mostly women in middle age.
Familial PBC is when PBC affects more than one member of the same family, and data suggest that first-degree relatives of PBC patients have an increased risk of developing the disease.
Most often, these familial clusters involve mother-daughter pairs, which is consistent with the female preponderance of the disease.
These clusters provide evidence towards a genetic basis underlying PBC.
However, clusters of nonrelated individuals have also been reported, giving strength to an environmental component.
Twin studies have demonstrated a high concordance for PBC in monozygotic twins and a low concordance among dizygotic twins.
In conclusion, studies of PBC in families clearly demonstrate that genetic, epigenetic, and environmental factors play a role in the development of the disease.
American Psychological Association (APA)
Smyk, Daniel S.& Cholongitas, Evangelos& Kriese, Stephen& Rigopoulou, Eirini I.& Bogdanos, Dimitrios P.. 2011. Primary Biliary Cirrhosis : Family Stories. Autoimmune Diseases،Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-453095
Modern Language Association (MLA)
Smyk, Daniel S.…[et al.]. Primary Biliary Cirrhosis : Family Stories. Autoimmune Diseases No. 2011 (2011), pp.1-11.
https://search.emarefa.net/detail/BIM-453095
American Medical Association (AMA)
Smyk, Daniel S.& Cholongitas, Evangelos& Kriese, Stephen& Rigopoulou, Eirini I.& Bogdanos, Dimitrios P.. Primary Biliary Cirrhosis : Family Stories. Autoimmune Diseases. 2011. Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-453095
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-453095