Primary Biliary Cirrhosis : Family Stories

Joint Authors

Bogdanos, Dimitrios P.
Kriese, Stephen
Cholongitas, Evangelos
Smyk, Daniel S.
Rigopoulou, Eirini I.

Source

Autoimmune Diseases

Issue

Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-11, 11 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2011-05-05

Country of Publication

Egypt

No. of Pages

11

Main Subjects

Diseases

Abstract EN

Primary biliary cirrhosis (PBC) is a chronic immune-mediated cholestatic liver disease of unknown aetiology which affects mostly women in middle age.

Familial PBC is when PBC affects more than one member of the same family, and data suggest that first-degree relatives of PBC patients have an increased risk of developing the disease.

Most often, these familial clusters involve mother-daughter pairs, which is consistent with the female preponderance of the disease.

These clusters provide evidence towards a genetic basis underlying PBC.

However, clusters of nonrelated individuals have also been reported, giving strength to an environmental component.

Twin studies have demonstrated a high concordance for PBC in monozygotic twins and a low concordance among dizygotic twins.

In conclusion, studies of PBC in families clearly demonstrate that genetic, epigenetic, and environmental factors play a role in the development of the disease.

American Psychological Association (APA)

Smyk, Daniel S.& Cholongitas, Evangelos& Kriese, Stephen& Rigopoulou, Eirini I.& Bogdanos, Dimitrios P.. 2011. Primary Biliary Cirrhosis : Family Stories. Autoimmune Diseases،Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-453095

Modern Language Association (MLA)

Smyk, Daniel S.…[et al.]. Primary Biliary Cirrhosis : Family Stories. Autoimmune Diseases No. 2011 (2011), pp.1-11.
https://search.emarefa.net/detail/BIM-453095

American Medical Association (AMA)

Smyk, Daniel S.& Cholongitas, Evangelos& Kriese, Stephen& Rigopoulou, Eirini I.& Bogdanos, Dimitrios P.. Primary Biliary Cirrhosis : Family Stories. Autoimmune Diseases. 2011. Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-453095

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-453095