GSK3 Function in the Brain during Development, Neuronal Plasticity, and Neurodegeneration
Joint Authors
Arias, Clorinda
Ortiz-Matamoros, Abril
Salcedo-Tello, Pamela
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-05-04
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
GSK3 has diverse functions, including an important role in brain pathology.
In this paper, we address the primary functions of GSK3 in development and neuroplasticity, which appear to be interrelated and to mediate age-associated neurological diseases.
Specifically, GSK3 plays a pivotal role in controlling neuronal progenitor proliferation and establishment of neuronal polarity during development, and the upstream and downstream signals modulating neuronal GSK3 function affect cytoskeletal reorganization and neuroplasticity throughout the lifespan.
Modulation of GSK3 in brain areas subserving cognitive function has become a major focus for treating neuropsychiatric and neurodegenerative diseases.
As a crucial node that mediates a variety of neuronal processes, GSK3 is proposed to be a therapeutic target for restoration of synaptic functioning and cognition, particularly in Alzheimer's disease.
American Psychological Association (APA)
Salcedo-Tello, Pamela& Ortiz-Matamoros, Abril& Arias, Clorinda. 2011. GSK3 Function in the Brain during Development, Neuronal Plasticity, and Neurodegeneration. International Journal of Alzheimer's Disease،Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-453105
Modern Language Association (MLA)
Salcedo-Tello, Pamela…[et al.]. GSK3 Function in the Brain during Development, Neuronal Plasticity, and Neurodegeneration. International Journal of Alzheimer's Disease No. 2011 (2011), pp.1-12.
https://search.emarefa.net/detail/BIM-453105
American Medical Association (AMA)
Salcedo-Tello, Pamela& Ortiz-Matamoros, Abril& Arias, Clorinda. GSK3 Function in the Brain during Development, Neuronal Plasticity, and Neurodegeneration. International Journal of Alzheimer's Disease. 2011. Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-453105
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-453105