Cytokines and Chemokines as Biomarkers of Community-Acquired Bacterial Infection
Joint Authors
Lawrence, David A.
Davidová, Alžběta
Chalupa, Pavel
Marešová, Vilma
Beran, Ondřej
Holub, Michal
Andersen, Nancy
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-16
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Routinely used biomarkers of bacterial etiology of infection, such as C-reactive protein and procalcitonin, have limited usefulness for evaluation of infections since their expression is enhanced by a number of different conditions.
Therefore, several inflammatory cytokines and chemokines were analyzed with sera from patients hospitalized for moderate bacterial and viral infectious diseases.
In total, 57 subjects were enrolled: 21 patients with community-acquired bacterial infections, 26 patients with viral infections, and 10 healthy subjects (control cohorts).
The laboratory analyses were performed using Luminex technology, and the following molecules were examined: IL-1Ra, IL-2, IL-4, IL-6, IL-8, TNF-α, INF-γ, MIP-1β, and MCP-1.
Bacterial etiology of infection was associated with significantly (P<0.001) elevated serum concentrations of IL-1Ra, IL-2, IL-6, and TNF-α in comparison to levels observed in the sera of patients with viral infections.
In the patients with bacterial infections, IL-1Ra and IL-8 demonstrated positive correlation with C-reactive protein, whereas, IL-1Ra, TNF-α, and MCP-1 correlated with procalcitonin.
Furthermore, elevated levels of IL-1Ra, IL-6, and TNF-α decreased within 3 days of antibiotic therapy to levels observed in control subjects.
The results show IL-1Ra as a potential useful biomarker of community-acquired bacterial infection.
American Psychological Association (APA)
Holub, Michal& Lawrence, David A.& Andersen, Nancy& Davidová, Alžběta& Beran, Ondřej& Marešová, Vilma…[et al.]. 2013. Cytokines and Chemokines as Biomarkers of Community-Acquired Bacterial Infection. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-453126
Modern Language Association (MLA)
Holub, Michal…[et al.]. Cytokines and Chemokines as Biomarkers of Community-Acquired Bacterial Infection. Mediators of Inflammation No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-453126
American Medical Association (AMA)
Holub, Michal& Lawrence, David A.& Andersen, Nancy& Davidová, Alžběta& Beran, Ondřej& Marešová, Vilma…[et al.]. Cytokines and Chemokines as Biomarkers of Community-Acquired Bacterial Infection. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-453126
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-453126