Smart Integrated Sensor for Multiple Detections of Glucose and L-Lactate Using On-Chip Electrochemical System
Joint Authors
Okumura, Koichi
Sawada, Kazuaki
Lim, Byounghyun
Yamazaki, Tomoyuki
Ikeda, Takaaki
Ishida, Makoto
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-16
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Multiple sensor electrodes, a supplementary electrode, a reference electrode, and signal-processing circuits were integrated on a single chip to develop a chip-shaped electrochemical sensing system.
L-lactate and glucose were measured using on-chip working electrodes modified by polyion complex to immobilize lactate oxidase and glucose oxidase, respectively.
Cyclic voltammetry measurements were conducted using an on-chip potentiostat.
Selective and quantitative detection of glucose and L-lactate and the interference behavior were studied.
Hydrogen peroxide generated by enzymatic reactions was detected by an increase in anodic oxidation current.
Reaction currents at +0.7 V versus Ag/AgCl were used to obtain calibration plots.
The measured dynamic ranges for L-lactate and glucose were 0.2–1.0 mM and 2.0–8.0 mM, respectively.
The sensitivities were 65 nA/mM and 15 nA/mM, respectively, using a working electrode of 0.5 mm2.
The 3σ detection limit was 0.19 mM and 1.1 mM, respectively.
We have achieved multiple biomaterial detections on a circuit-equipped single chip.
This integrated electrochemical sensor chip could be the best candidate for realizing point-of-care testing due to its portability and potential for mass production.
American Psychological Association (APA)
Yamazaki, Tomoyuki& Ikeda, Takaaki& Lim, Byounghyun& Okumura, Koichi& Ishida, Makoto& Sawada, Kazuaki. 2011. Smart Integrated Sensor for Multiple Detections of Glucose and L-Lactate Using On-Chip Electrochemical System. Journal of Sensors،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-453140
Modern Language Association (MLA)
Yamazaki, Tomoyuki…[et al.]. Smart Integrated Sensor for Multiple Detections of Glucose and L-Lactate Using On-Chip Electrochemical System. Journal of Sensors No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-453140
American Medical Association (AMA)
Yamazaki, Tomoyuki& Ikeda, Takaaki& Lim, Byounghyun& Okumura, Koichi& Ishida, Makoto& Sawada, Kazuaki. Smart Integrated Sensor for Multiple Detections of Glucose and L-Lactate Using On-Chip Electrochemical System. Journal of Sensors. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-453140
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-453140