Oxidative Stress in Chagas Disease
Joint Authors
Wen, Jian-Jun
Garg, Nisha Jain
Gupta, Shivali
Source
Interdisciplinary Perspectives on Infectious Diseases
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-06-14
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
There is growing evidence to suggest that chagasic myocardia are exposed to sustained oxidative stress induced injuries that may contribute to disease progression.
Trypanosoma cruzi invasion- and replication-mediated cellular injuries and immune-mediated cytotoxic reactions are the common source of reactive oxygen species (ROS) during acute infection.
Mitochondria are proposed to be the major source of ROS in chronic chagasic hearts.
However, it has not been established yet, whether mitochondrial dysfunction is a causative factor in chagasic cardiomyopathy or a consequence of other pathological events.
A better understanding of oxidative stress in relation to cardiac tissue damage would be useful in the evaluation of its true role in the pathogenesis of Chagas disease and other heart diseases.
In this review, we discuss the evidence for increased oxidative stress in chagasic disease, with emphasis on mitochondrial abnormalities, and its role in sustaining oxidative stress in myocardium.
American Psychological Association (APA)
Gupta, Shivali& Wen, Jian-Jun& Garg, Nisha Jain. 2009. Oxidative Stress in Chagas Disease. Interdisciplinary Perspectives on Infectious Diseases،Vol. 2009, no. 2009, pp.1-8.
https://search.emarefa.net/detail/BIM-453146
Modern Language Association (MLA)
Gupta, Shivali…[et al.]. Oxidative Stress in Chagas Disease. Interdisciplinary Perspectives on Infectious Diseases No. 2009 (2009), pp.1-8.
https://search.emarefa.net/detail/BIM-453146
American Medical Association (AMA)
Gupta, Shivali& Wen, Jian-Jun& Garg, Nisha Jain. Oxidative Stress in Chagas Disease. Interdisciplinary Perspectives on Infectious Diseases. 2009. Vol. 2009, no. 2009, pp.1-8.
https://search.emarefa.net/detail/BIM-453146
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-453146