Numerical Simulation of Solid Tumor Blood Perfusion and Drug Delivery during the “Vascular Normalization Window” with Antiangiogenic Therapy
Joint Authors
Xu, Shi-xiong
Long, Quan
Cai, Yan
Yao, Wei
Lv, Jie
Zhou, Yu
Cao, Jin-feng
Source
Journal of Applied Mathematics
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-02
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
To investigate the influence of vascular normalization on solid tumor blood perfusion and drug delivery, we used the generated blood vessel network for simulations.
Considering the hemodynamic parameters changing after antiangiogenic therapies, the results show that the interstitial fluid pressure (IFP) in tumor tissue domain decreases while the pressure gradient increases during the normalization window.
The decreased IFP results in more efficient delivery of conventional drugs to the targeted cancer cells.
The outcome of therapies will improve if the antiangiogenic therapies and conventional therapies are carefully scheduled.
American Psychological Association (APA)
Lv, Jie& Cao, Jin-feng& Cai, Yan& Zhou, Yu& Long, Quan& Yao, Wei…[et al.]. 2011. Numerical Simulation of Solid Tumor Blood Perfusion and Drug Delivery during the “Vascular Normalization Window” with Antiangiogenic Therapy. Journal of Applied Mathematics،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-453150
Modern Language Association (MLA)
Lv, Jie…[et al.]. Numerical Simulation of Solid Tumor Blood Perfusion and Drug Delivery during the “Vascular Normalization Window” with Antiangiogenic Therapy. Journal of Applied Mathematics No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-453150
American Medical Association (AMA)
Lv, Jie& Cao, Jin-feng& Cai, Yan& Zhou, Yu& Long, Quan& Yao, Wei…[et al.]. Numerical Simulation of Solid Tumor Blood Perfusion and Drug Delivery during the “Vascular Normalization Window” with Antiangiogenic Therapy. Journal of Applied Mathematics. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-453150
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-453150