The Retinal Pigment Epithelium : Something More than a Constituent of the Blood-Retinal Barrier—Implications for the Pathogenesis of Diabetic Retinopathy
Joint Authors
Garcia-Ramírez, Marta
Hernández, Cristina
Simó, Rafael
Corraliza, Lídia
Villarroel, Marta
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-02-17
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
The retinal pigment epithelium (RPE) is an specialized epithelium lying in the interface between the neural retina and the choriocapillaris where it forms the outer blood-retinal barrier (BRB).
The main functions of the RPE are the following: (1) transport of nutrients, ions, and water, (2) absorption of light and protection against photooxidation, (3) reisomerization of all-trans-retinal into 11-cis-retinal, which is crucial for the visual cycle, (4) phagocytosis of shed photoreceptor membranes, and (5) secretion of essential factors for the structural integrity of the retina.
An overview of these functions will be given.
Most of the research on the physiopathology of diabetic retinopathy has been focused on the impairment of the neuroretina and the breakdown of the inner BRB.
By contrast, the effects of diabetes on the RPE and in particular on its secretory activity have received less attention.
In this regard, new therapeutic strategies addressed to modulating RPE impairment are warranted.
American Psychological Association (APA)
Simó, Rafael& Villarroel, Marta& Corraliza, Lídia& Hernández, Cristina& Garcia-Ramírez, Marta. 2010. The Retinal Pigment Epithelium : Something More than a Constituent of the Blood-Retinal Barrier—Implications for the Pathogenesis of Diabetic Retinopathy. Journal of Biomedicine and Biotechnology،Vol. 2010, no. 2010, pp.1-15.
https://search.emarefa.net/detail/BIM-453182
Modern Language Association (MLA)
Simó, Rafael…[et al.]. The Retinal Pigment Epithelium : Something More than a Constituent of the Blood-Retinal Barrier—Implications for the Pathogenesis of Diabetic Retinopathy. Journal of Biomedicine and Biotechnology No. 2010 (2010), pp.1-15.
https://search.emarefa.net/detail/BIM-453182
American Medical Association (AMA)
Simó, Rafael& Villarroel, Marta& Corraliza, Lídia& Hernández, Cristina& Garcia-Ramírez, Marta. The Retinal Pigment Epithelium : Something More than a Constituent of the Blood-Retinal Barrier—Implications for the Pathogenesis of Diabetic Retinopathy. Journal of Biomedicine and Biotechnology. 2010. Vol. 2010, no. 2010, pp.1-15.
https://search.emarefa.net/detail/BIM-453182
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-453182