Investigation of Homocysteine-Pathway-Related Variants in Essential Hypertension
Joint Authors
Lea, Rodney A.
Lason, Marta V.
Griffiths, Lyn R.
Szvetko, Attila L.
Fowdar, Javed Y.
Source
International Journal of Hypertension
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-23
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Hyperhomocysteinemia (hHcy) has been associated with an increased risk of cardiovascular disease and stroke.
Essential hypertension (EH), a polygenic condition, has also been associated with increased risk of cardiovascular related disorders.
To investigate the role of the homocysteine (Hcy) metabolism pathway in hypertension we conducted a case-control association study of Hcy pathway gene variants in a cohort of Caucasian hypertensives and age- and sex-matched normotensives.
We genotyped two polymorphisms in the methylenetetrahydrofolate reductase gene (MTHFR C677T and MTHFR A1298C), one polymorphism in the methionine synthase reductase gene (MTRR A66G), and one polymorphism in the methylenetetrahydrofolate dehydrogenase 1 gene (MTHFD1 G1958A) and assessed their association with hypertension using chi-square analysis.
We also performed a multifactor dimensionality reduction (MDR) analysis to investigate any potential epistatic interactions among the four polymorphisms and EH.
None of the four polymorphisms was significantly associated with EH and although we found a moderate synergistic interaction between MTHFR A1298C and MTRR A66G, the association of the interaction model with EH was not statistically significant (P=0.2367).
Our findings therefore suggest no individual or interactive association between four prominent Hcy pathway markers and EH.
American Psychological Association (APA)
Fowdar, Javed Y.& Lason, Marta V.& Szvetko, Attila L.& Lea, Rodney A.& Griffiths, Lyn R.. 2012. Investigation of Homocysteine-Pathway-Related Variants in Essential Hypertension. International Journal of Hypertension،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-453202
Modern Language Association (MLA)
Fowdar, Javed Y.…[et al.]. Investigation of Homocysteine-Pathway-Related Variants in Essential Hypertension. International Journal of Hypertension No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-453202
American Medical Association (AMA)
Fowdar, Javed Y.& Lason, Marta V.& Szvetko, Attila L.& Lea, Rodney A.& Griffiths, Lyn R.. Investigation of Homocysteine-Pathway-Related Variants in Essential Hypertension. International Journal of Hypertension. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-453202
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-453202