Intermittent Atrioventricular Block following Fingolimod Initiation
Joint Authors
Kilidireas, Costas
Grigoriou, A.
Andreadou, Elisabeth
Stamboulis, E.
Gialafos, E.
Gerakoulis, S.
Haina, V.
Source
Case Reports in Neurological Medicine
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-05
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
A 47-year-old female patient with multiple sclerosis (MS) developed symptomatic intermittent 2nd degree atrioventricular block (AVB) of five-hour duration, five hours after the first two doses of fingolimod, that resolved completely.
Frequency domain analysis of heart rate variability (HRV) revealed increased parasympathetic activity and decreased sympathetic tone, while modified Ewing tests were suggestive of impaired cardiac sympathetic function.
We hypothesize that expression of this particular arrhythmia might be related to autonomic nervous system (ANS) dysfunction due to demyelinating lesions in the upper thoracic spinal cord, possibly augmented by the parasympathetic effect of the drug.
American Psychological Association (APA)
Gialafos, E.& Gerakoulis, S.& Grigoriou, A.& Haina, V.& Kilidireas, Costas& Stamboulis, E.…[et al.]. 2014. Intermittent Atrioventricular Block following Fingolimod Initiation. Case Reports in Neurological Medicine،Vol. 2014, no. 2014, pp.1-4.
https://search.emarefa.net/detail/BIM-453228
Modern Language Association (MLA)
Gialafos, E.…[et al.]. Intermittent Atrioventricular Block following Fingolimod Initiation. Case Reports in Neurological Medicine No. 2014 (2014), pp.1-4.
https://search.emarefa.net/detail/BIM-453228
American Medical Association (AMA)
Gialafos, E.& Gerakoulis, S.& Grigoriou, A.& Haina, V.& Kilidireas, Costas& Stamboulis, E.…[et al.]. Intermittent Atrioventricular Block following Fingolimod Initiation. Case Reports in Neurological Medicine. 2014. Vol. 2014, no. 2014, pp.1-4.
https://search.emarefa.net/detail/BIM-453228
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-453228