Maternal BMI, IGF-I Levels, and Birth Weight in African American and White Infants
Joint Authors
Hoyo, Cathrine
Forman, Michele R.
Henry, Nikki
Vidal, Adriana C.
Jirtle, Randy
Schildkraut, Joellen M.
Overcash, Francine
Murtha, Amy P.
Demark-Wahnefried, Wendy
Fortner, Kimberly
Murphy, Susan K.
Kurtzberg, Joanne
Source
International Journal of Pediatrics
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-03
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
At birth, elevated IGF-I levels have been linked to birth weight extremes; high birth weight and low birth weight are risk factors for adult-onset chronic diseases including obesity, cardiovascular disease, and type 2 diabetes.
We examined associations between plasma IGF-I levels and birth weight among infants born to African American and White obese and nonobese women.
Prepregnancy weight and height were assessed among 251 pregnant women and anthropometric measurements of full term infants (≥37 weeks of gestation) were taken at birth.
Circulating IGF-I was measured by ELISA in umbilical cord blood plasma.
Linear regression models were utilized to examine associations between birth weight and high IGF-I, using the bottom two tertiles as referents.
Compared with infants with lower IGF-I levels (≤3rd tertile), those with higher IGF-I levels (>3rd tertile) were 130 g heavier at birth, (β-coefficient=230, se=58.0, P=0.0001), after adjusting for gender, race/ethnicity, gestational age, delivery route, maternal BMI and smoking.
Stratified analyses suggested that these associations are more pronounced in infants born to African American women and women with BMI ≥30 kg/m2; the cross product term for IGF-I and maternal BMI was statistically significant (P≤0.0004).
Our findings suggest that the association between IGF-I levels and birth weight depends more on maternal obesity than African American race/ethnicity.
American Psychological Association (APA)
Vidal, Adriana C.& Murtha, Amy P.& Murphy, Susan K.& Fortner, Kimberly& Overcash, Francine& Henry, Nikki…[et al.]. 2013. Maternal BMI, IGF-I Levels, and Birth Weight in African American and White Infants. International Journal of Pediatrics،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-453235
Modern Language Association (MLA)
Vidal, Adriana C.…[et al.]. Maternal BMI, IGF-I Levels, and Birth Weight in African American and White Infants. International Journal of Pediatrics No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-453235
American Medical Association (AMA)
Vidal, Adriana C.& Murtha, Amy P.& Murphy, Susan K.& Fortner, Kimberly& Overcash, Francine& Henry, Nikki…[et al.]. Maternal BMI, IGF-I Levels, and Birth Weight in African American and White Infants. International Journal of Pediatrics. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-453235
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-453235