Increased Survivorship and Altered Cytokine Profile from Treatment of Influenza A H1N1-Infected Mice with Ekybion : A Drug Complex of Natural Extracts and Inorganic Compounds
Joint Authors
Tepper, Samuel E.
Lupfer, Christopher
Patton, Kristin M.
Pastey, Manoj
Maselko, Maciej
Besnouin, Didier
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-10-19
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Ekybion is a drug complex of 16 natural extracts and inorganic compounds designed to treat a variety of respiratory pathogens of bacterial and viral origin.
It is licensed throughout Europe for the treatment of respiratory tract infections from equine parainfluenza type 3 and equine herpes virus type 1 in equine stables.
The purpose of this paper was to test the efficacy of Ekybion on a well-developed animal model of influenza A infection and determine a mode of action.
Experiments were performed with Balb/c mice infected with a lethal dose of influenza A/PR/8/34 H1N1 virus and treated with nebulized Ekybion every 8 h in a time-dependant or dose-dependant fashion.
These experiments showed that mice treated prior to infection with Ekybion had a higher survival rates (~46%) compared with untreated animals (~0%).
Paradoxically, these mice showed no significant difference in lung virus titer or weight loss.
There was, however, a decrease in the level of GM-CSF, IL-6, and G-CSF cytokines in the lungs of Ekybion-treated, infected mice.
It is possible that decreases in proinflammatory cytokines may have contributed to increased survivorship in Ekybion-treated influenza-infected mice.
American Psychological Association (APA)
Lupfer, Christopher& Besnouin, Didier& Tepper, Samuel E.& Maselko, Maciej& Patton, Kristin M.& Pastey, Manoj. 2010. Increased Survivorship and Altered Cytokine Profile from Treatment of Influenza A H1N1-Infected Mice with Ekybion : A Drug Complex of Natural Extracts and Inorganic Compounds. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-453283
Modern Language Association (MLA)
Lupfer, Christopher…[et al.]. Increased Survivorship and Altered Cytokine Profile from Treatment of Influenza A H1N1-Infected Mice with Ekybion : A Drug Complex of Natural Extracts and Inorganic Compounds. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-453283
American Medical Association (AMA)
Lupfer, Christopher& Besnouin, Didier& Tepper, Samuel E.& Maselko, Maciej& Patton, Kristin M.& Pastey, Manoj. Increased Survivorship and Altered Cytokine Profile from Treatment of Influenza A H1N1-Infected Mice with Ekybion : A Drug Complex of Natural Extracts and Inorganic Compounds. Evidence-Based Complementary and Alternative Medicine. 2010. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-453283
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-453283