Hymenoptera Venom Immunotherapy : Tolerance and Efficacy of an Ultrarush Protocol versus a Rush and a Slow Conventional Protocol
Joint Authors
Florio, Giovanni
Giuliano, Ada
Genovese, Arturo
Spadaro, Giuseppe
Patella, Vincenzo
Marone, Gianni
Oricchio, Carmine
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-24
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background and Objective.
Various venom immunotherapy (VIT) protocols are available for Hymenoptera allergy.
Although adverse reactions (ADRs) to VIT are widely reported, controlled trials are still needed.
We conducted a randomized prospective study to evaluate ADRs and the efficacy of three VIT regimens.
Methods.
76 patients with Hymenoptera allergy, aged 16–76 years, were randomized to receive an ultrarush protocol (group A: 27 patients), a rush protocol (group B: 25), or a slow protocol (group C: 24).
Aqueous venom extract was used in incremental phase and an adsorbed depot in maintenance phase.
ADRs and accidental Hymenoptera stings during VIT were used to evaluate efficacy.
Results.
During incremental treatment, ADRs occurred in 1.99%, 3.7%, and 3.9% of patients in groups A, B, and C, and in 0.99%, 1.46%, and 2.7%, respectively, during maintenance.
ADRs were significantly fewer in group A (incremental + maintenance phase) than in group C (1.29% versus 3.2%; P=0.013).
Reactions to accidental Hymenoptera stings did not differ among groups (1.1%, 1.2%, and 1.1%).
Conclusion.
Ultrarush was as effective as the rush and slow protocols and was associated with a low incidence of reactions to stings.
This study indicates that ultrarush VIT is a valid therapeutic option for Hymenoptera allergy.
American Psychological Association (APA)
Patella, Vincenzo& Florio, Giovanni& Giuliano, Ada& Oricchio, Carmine& Spadaro, Giuseppe& Marone, Gianni…[et al.]. 2012. Hymenoptera Venom Immunotherapy : Tolerance and Efficacy of an Ultrarush Protocol versus a Rush and a Slow Conventional Protocol. Journal of Allergy،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-453293
Modern Language Association (MLA)
Patella, Vincenzo…[et al.]. Hymenoptera Venom Immunotherapy : Tolerance and Efficacy of an Ultrarush Protocol versus a Rush and a Slow Conventional Protocol. Journal of Allergy No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-453293
American Medical Association (AMA)
Patella, Vincenzo& Florio, Giovanni& Giuliano, Ada& Oricchio, Carmine& Spadaro, Giuseppe& Marone, Gianni…[et al.]. Hymenoptera Venom Immunotherapy : Tolerance and Efficacy of an Ultrarush Protocol versus a Rush and a Slow Conventional Protocol. Journal of Allergy. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-453293
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-453293