β-Catenin Signalling in Glioblastoma Multiforme and Glioma-Initiating Cells
Joint Authors
Nogués, Pere
Nager, Mireia
Medina, Loreta
Herreros, Judit
Bhardwaj, Deepshikha
Cantí, Carles
Source
Chemotherapy Research and Practice
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-12
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Glioblastoma multiforme (GBM) is a commonly occurring brain tumor with a poor prognosis.
GBM can develop both “de novo” or evolve from a previous astrocytoma and is characterized by high proliferation and infiltration into the surrounding tissue.
Following treatment (surgery, radiotherapy, and chemotherapy), tumors often reappear.
Glioma-initiating cells (GICs) have been identified in GBM and are thought to be responsible for tumors initiation, their continued growth, and recurrence.
β-catenin, a component of the cell-cell adhesion complex and of the canonical Wnt pathway, regulates proliferation, adhesion, and migration in different cell types.
β-catenin and components of the Wnt canonical pathway are commonly overexpressed in GBM.
Here, we review previous work on the role of Wnt/β-catenin signalling in glioma initiation, proliferation, and invasion.
Understanding the molecular mechanisms regulating GIC biology and glioma progression may help in identifying novel therapeutic targets for GBM treatment.
American Psychological Association (APA)
Nager, Mireia& Bhardwaj, Deepshikha& Cantí, Carles& Medina, Loreta& Nogués, Pere& Herreros, Judit. 2012. β-Catenin Signalling in Glioblastoma Multiforme and Glioma-Initiating Cells. Chemotherapy Research and Practice،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-453299
Modern Language Association (MLA)
Nager, Mireia…[et al.]. β-Catenin Signalling in Glioblastoma Multiforme and Glioma-Initiating Cells. Chemotherapy Research and Practice No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-453299
American Medical Association (AMA)
Nager, Mireia& Bhardwaj, Deepshikha& Cantí, Carles& Medina, Loreta& Nogués, Pere& Herreros, Judit. β-Catenin Signalling in Glioblastoma Multiforme and Glioma-Initiating Cells. Chemotherapy Research and Practice. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-453299
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-453299