β-Catenin Signalling in Glioblastoma Multiforme and Glioma-Initiating Cells

Abstract EN

Glioblastoma multiforme (GBM) is a commonly occurring brain tumor with a poor prognosis.

GBM can develop both “de novo” or evolve from a previous astrocytoma and is characterized by high proliferation and infiltration into the surrounding tissue.

Following treatment (surgery, radiotherapy, and chemotherapy), tumors often reappear.

Glioma-initiating cells (GICs) have been identified in GBM and are thought to be responsible for tumors initiation, their continued growth, and recurrence.

β-catenin, a component of the cell-cell adhesion complex and of the canonical Wnt pathway, regulates proliferation, adhesion, and migration in different cell types.

β-catenin and components of the Wnt canonical pathway are commonly overexpressed in GBM.

Here, we review previous work on the role of Wnt/β-catenin signalling in glioma initiation, proliferation, and invasion.

Understanding the molecular mechanisms regulating GIC biology and glioma progression may help in identifying novel therapeutic targets for GBM treatment.