Uptake of Photosensitizer 2-Devinyl-2-(1-methoxylethyl) Chlorin f in Human Breast Cancer Cells : A Diffusion Kinetics Study
Joint Authors
Tang, Guo-Qing
Lin, Lie
Yang, Jun-Hong
Zhang, Feng
Zhang, Lei
Yao, Jian-Zhong
Chen, Ping
Mao, Song-Cheng
Ma, Yun-Feng
Bai, Hua
Source
International Journal of Photoenergy
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-01-12
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The kinetics of photosensitizer 2-devinyl-2-(1-methoxylethyl) chlorin f (CPD4) uptake in MCF-7 human breast cancer cells is described by a diffusion kinetics model and experimentally investigated using laser scanning confocal microscopy (LSCM).
CPD4 permeated into MCF-7 cells with increasing incubation time, which was followed by its binding to cell organelles.
Subcellular distribution study revealed that CPD4 was primarily localized on the mitochondria and membranes, supporting that the mode of transmembrane transport was diffusion.
A kinetics model describing CPD4 passing through the plasma membrane of MCF-7 cells was proposed based on Fick's first law of diffusion.
The kinetics of cellular uptake of CPD4 was studied by three-dimensional LSCM.
By fitting the experimental data using the above model, important cellular uptake and distribution parameters were obtained, which are of clinical significance in photodynamic therapy.
American Psychological Association (APA)
Chen, Ping& Zhang, Feng& Zhang, Lei& Mao, Song-Cheng& Lin, Lie& Bai, Hua…[et al.]. 2012. Uptake of Photosensitizer 2-Devinyl-2-(1-methoxylethyl) Chlorin f in Human Breast Cancer Cells : A Diffusion Kinetics Study. International Journal of Photoenergy،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-453302
Modern Language Association (MLA)
Chen, Ping…[et al.]. Uptake of Photosensitizer 2-Devinyl-2-(1-methoxylethyl) Chlorin f in Human Breast Cancer Cells : A Diffusion Kinetics Study. International Journal of Photoenergy No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-453302
American Medical Association (AMA)
Chen, Ping& Zhang, Feng& Zhang, Lei& Mao, Song-Cheng& Lin, Lie& Bai, Hua…[et al.]. Uptake of Photosensitizer 2-Devinyl-2-(1-methoxylethyl) Chlorin f in Human Breast Cancer Cells : A Diffusion Kinetics Study. International Journal of Photoenergy. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-453302
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-453302