Preparation and Evaluation of Intravaginal Ring Containing Drospirenone
Joint Authors
Duan, Xue-Yan
Li, Chun-Xiao
Liu, Ying
Zhang, Ying
Ning, Mei-Ying
Source
Advances in Pharmacological Sciences
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-01-17
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
In the present study, we investigated the feasibility of the vaginal administration of drospirenone silicone IVR.
The in vitro release characteristics of matrix-type and reservoir-type IVR were compared under sink conditions in 21 days.
At the same time, API excipients compatibility and preformulation study was performed by HPLC, IR, and DSC methods.
Biocompatibility of reservoir system was evaluated by tolerability on tissue level in rats.
It was found that, under strong light exposure, high temperature, and high humidity conditions, drospirenone and excipients had no significant interactions.
The daily release of reservoir-type IVR was about 0.5 mg/d sustaining 21 days, which significantly decreased the burst effect compared with the matrix system.
When drospirenone was modified by the PVPk30 in the reservoir system formulation, the daily release rate increased to 1.0 mg/d sustaining 21 days.
The cumulative release of reservoir-type IVR was fitted to zero release equation.
In addition, biocompatibility of drospirenone IVR system in this dosage is safe.
It is feasibility feasibile to further developed for safe, convenient, and effective contraceptive drug delivery with reduced dosing interval.
American Psychological Association (APA)
Zhang, Ying& Li, Chun-Xiao& Ning, Mei-Ying& Duan, Xue-Yan& Liu, Ying. 2013. Preparation and Evaluation of Intravaginal Ring Containing Drospirenone. Advances in Pharmacological Sciences،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-453305
Modern Language Association (MLA)
Zhang, Ying…[et al.]. Preparation and Evaluation of Intravaginal Ring Containing Drospirenone. Advances in Pharmacological Sciences No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-453305
American Medical Association (AMA)
Zhang, Ying& Li, Chun-Xiao& Ning, Mei-Ying& Duan, Xue-Yan& Liu, Ying. Preparation and Evaluation of Intravaginal Ring Containing Drospirenone. Advances in Pharmacological Sciences. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-453305
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-453305