Is There a Link between Mitochondrial Reserve Respiratory Capacity and Aging?
Joint Authors
Marcker, Maiken Lise
Hansen, Thomas Lau
Singh, Keshav K.
Desler, Claus
Frederiksen, Jane Bruun
Juel Rasmussen, Lene
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-05
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Pharmacy, Health & Medical Sciences
Abstract EN
Oxidative phosphorylation is an indispensable resource of ATP in tissues with high requirement of energy.
If the ATP demand is not met, studies suggest that this will lead to senescence and cell death in the affected tissue.
The term reserve respiratory capacity or spare respiratory capacity is used to describe the amount of extra ATP that can be produced by oxidative phosphorylation in case of a sudden increase in energy demand.
Depletion of the reserve respiratory capacity has been related to a range of pathologies affecting high energy requiring tissues.
During aging of an organism, and as a result of mitochondrial dysfunctions, the efficiency of oxidative phosphorylation declines.
Based on examples from the energy requiring tissues such as brain, heart, and skeletal muscle, we propose that the age-related decline of oxidative phosphorylation decreases the reserve respiratory capacity of the affected tissue, sensitizes the cells to surges in ATP demand, and increases the risk of resulting pathologies.
American Psychological Association (APA)
Desler, Claus& Hansen, Thomas Lau& Frederiksen, Jane Bruun& Marcker, Maiken Lise& Singh, Keshav K.& Juel Rasmussen, Lene. 2012. Is There a Link between Mitochondrial Reserve Respiratory Capacity and Aging?. Journal of Aging Research،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-453318
Modern Language Association (MLA)
Desler, Claus…[et al.]. Is There a Link between Mitochondrial Reserve Respiratory Capacity and Aging?. Journal of Aging Research No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-453318
American Medical Association (AMA)
Desler, Claus& Hansen, Thomas Lau& Frederiksen, Jane Bruun& Marcker, Maiken Lise& Singh, Keshav K.& Juel Rasmussen, Lene. Is There a Link between Mitochondrial Reserve Respiratory Capacity and Aging?. Journal of Aging Research. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-453318
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-453318