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Clinical Study of the Relation between Mucosal Healing and Long-Term Outcomes in Ulcerative Colitis
Joint Authors
Koizumi, Wasaburo
Mukae, Miyuki
Kobayashi, Kiyonori
Yokoyama, Kaoru
Sada, Miwa
Source
Gastroenterology Research and Practice
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-05-09
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background and Objectives.
Mucosal healing (MH) is considered an important therapeutic goal in ulcerative colitis (UC).
We evaluate the severity of intestinal inflammation and clarify the relation between MH and long-term outcomes.
Methods.
The study group comprised 38 patients with UC in clinical remission on total colonoscopy who were followed up for at least 5 years.
Clinical remission was defined as a Mayo score of 0 for both stool frequency and rectal bleeding.
Colonoscopic findings were evaluated into 4 grades according to the Mayo endoscopic subscore (MES).
Results.
During clinical remission, the MES was 0 in only 24% of the patients, 1 in 40%, 2 in 26%, and 3 in 10%.
Seventy-six percent of the patients thus had active disease on colonoscopy.
After initial colonoscopy, the cumulative rate of remission maintenance was 100% in MES 0, 1 in 93%, 2 in 70%, and 3 in 50% at 6 months and 78%, 40%, 10%, and 0%, respectively, at 5 years (P<0.001).
Conclusion.
Many patients with UC in clinical remission have active lesions.
Patients with a higher MES have a higher rate of recurrence.
To improve long-term outcomes, an MES of 0 should be the treatment goal.
American Psychological Association (APA)
Yokoyama, Kaoru& Kobayashi, Kiyonori& Mukae, Miyuki& Sada, Miwa& Koizumi, Wasaburo. 2013. Clinical Study of the Relation between Mucosal Healing and Long-Term Outcomes in Ulcerative Colitis. Gastroenterology Research and Practice،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-453355
Modern Language Association (MLA)
Yokoyama, Kaoru…[et al.]. Clinical Study of the Relation between Mucosal Healing and Long-Term Outcomes in Ulcerative Colitis. Gastroenterology Research and Practice No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-453355
American Medical Association (AMA)
Yokoyama, Kaoru& Kobayashi, Kiyonori& Mukae, Miyuki& Sada, Miwa& Koizumi, Wasaburo. Clinical Study of the Relation between Mucosal Healing and Long-Term Outcomes in Ulcerative Colitis. Gastroenterology Research and Practice. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-453355
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-453355