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Computational Prediction of Protein-Protein Interactions of Human Tyrosinase
Joint Authors
Qian, Guo-Ying
Wang, Su-Fang
Han, Hong-Yan
Lee, Jinhyuk
Oh, Sangho
Si, Yue-Xiu
Wang, Zhi-Jiang
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-26
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The various studies on tyrosinase have recently gained the attention of researchers due to their potential application values and the biological functions.
In this study, we predicted the 3D structure of human tyrosinase and simulated the protein-protein interactions between tyrosinase and three binding partners, four and half LIM domains 2 (FHL2), cytochrome b-245 alpha polypeptide (CYBA), and RNA-binding motif protein 9 (RBM9).
Our interaction simulations showed significant binding energy scores of −595.3 kcal/mol for FHL2, −859.1 kcal/mol for CYBA, and −821.3 kcal/mol for RBM9.
We also investigated the residues of each protein facing toward the predicted site of interaction with tyrosinase.
Our computational predictions will be useful for elucidating the protein-protein interactions of tyrosinase and studying its binding mechanisms.
American Psychological Association (APA)
Wang, Su-Fang& Oh, Sangho& Si, Yue-Xiu& Wang, Zhi-Jiang& Han, Hong-Yan& Lee, Jinhyuk…[et al.]. 2012. Computational Prediction of Protein-Protein Interactions of Human Tyrosinase. Enzyme Research،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-453362
Modern Language Association (MLA)
Wang, Su-Fang…[et al.]. Computational Prediction of Protein-Protein Interactions of Human Tyrosinase. Enzyme Research No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-453362
American Medical Association (AMA)
Wang, Su-Fang& Oh, Sangho& Si, Yue-Xiu& Wang, Zhi-Jiang& Han, Hong-Yan& Lee, Jinhyuk…[et al.]. Computational Prediction of Protein-Protein Interactions of Human Tyrosinase. Enzyme Research. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-453362
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-453362