Resistant Hypertension and Obstructive Sleep Apnea
Joint Authors
Patel, Nimesh K.
Khan, Akram
Khan, Supriya
O’Hearn, Daniel J.
Source
International Journal of Hypertension
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-05-28
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Hypertension (HTN) is a modifiable, highly prevalent risk factor for cardiovascular morbidity and renal dysfunction worldwide.
In the United States, HTN affects one in three adults, contributes to one out of every seven deaths and to nearly half of all cardiovascular disease-related deaths.
HTN is considered resistant when the blood pressure remains above goal despite lifestyle modification and administration of three antihypertensive agents of different classes including a diuretic.
Large population-based studies have suggested that obstructive sleep apnea (OSA) is a risk factor for resistant HTN.
The mechanism proposed is a pattern of intermittent hypoxia associated with hyperaldosteronism, increased sympathetic tone, endothelial dysfunction, and inflammation.
In this review we discuss the association between OSA and resistant HTN, the physiologic mechanisms linking OSA with resistant HTN, and the effect of continuous positive airway pressure therapy (CPAP) on blood pressure in patients with resistant HTN.
While the reduction in blood pressure with CPAP is usually modest in patients with OSA, a decrease of only a few mmHg in blood pressure can significantly reduce cardiovascular risk.
Patients presenting to a center specializing in management of hypertension should be screened and treated for OSA as a potentially modifiable risk factor.
American Psychological Association (APA)
Khan, Akram& Patel, Nimesh K.& O’Hearn, Daniel J.& Khan, Supriya. 2013. Resistant Hypertension and Obstructive Sleep Apnea. International Journal of Hypertension،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-453375
Modern Language Association (MLA)
Khan, Akram…[et al.]. Resistant Hypertension and Obstructive Sleep Apnea. International Journal of Hypertension No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-453375
American Medical Association (AMA)
Khan, Akram& Patel, Nimesh K.& O’Hearn, Daniel J.& Khan, Supriya. Resistant Hypertension and Obstructive Sleep Apnea. International Journal of Hypertension. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-453375
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-453375