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Electrochemical Oxidation of an Immunosuppressant, Mycophenolate Mofetil, and Its Assay in Pharmaceutical Formulations
Joint Authors
Seetharamappa, J.
Ramesh, K. C.
Prashanth, S. N.
Source
International Journal of Electrochemistry
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-10
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Electrochemical oxidation of mycophenolate mofetil (MMF) has been studied at a glassy carbon electrode in aqueous solution over a wide pH range.
MMF was oxidized on glassy carbon electrode (GCE) by an irreversible process that was controlled mainly by diffusion.
The irreversibility of the electrode process was verified by different criteria.
A probable mechanism for electrochemical oxidation of MMF was proposed.
Differential-pulse voltammogram of the drug showed two oxidation peaks at 0.631 V and at 0.921 V (verses SCE) in phosphate buffer of pH 6.0.
This process could be used to determine MMF in the concentration range of 5.0×10−7 to 7.5×10−4 M with a limit of detection of 1.48×10−7 M.
The method was successfully applied for the analysis of MMF in pure and dosage forms and in biological fluids.
American Psychological Association (APA)
Prashanth, S. N.& Ramesh, K. C.& Seetharamappa, J.. 2011. Electrochemical Oxidation of an Immunosuppressant, Mycophenolate Mofetil, and Its Assay in Pharmaceutical Formulations. International Journal of Electrochemistry،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-453380
Modern Language Association (MLA)
Prashanth, S. N.…[et al.]. Electrochemical Oxidation of an Immunosuppressant, Mycophenolate Mofetil, and Its Assay in Pharmaceutical Formulations. International Journal of Electrochemistry No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-453380
American Medical Association (AMA)
Prashanth, S. N.& Ramesh, K. C.& Seetharamappa, J.. Electrochemical Oxidation of an Immunosuppressant, Mycophenolate Mofetil, and Its Assay in Pharmaceutical Formulations. International Journal of Electrochemistry. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-453380
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-453380