Bai-Hu-Tang, Ancient Chinese Medicine Formula, May Provide a New Complementary Treatment Option for Sepsis
Joint Authors
Li, Tsai-Chung
Su, Yi-Chang
Lee, Cheng-Hung
Chen, Yun-An
Lin, Chien-Jung
Lin, Sunny Jui-Shan
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-05-15
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Bai-Hu-Tang (BHT) has been broadly applied to treating the early stage of acute infection with systemic inflammation for two thousand years in Chinese medicine.
We explore whether BHT is beneficial in treating sepsis and its effects on proinflammatory cytokine, interleukin-6, and anti-inflammatory cytokine interleukin-10, in which both play key roles in the progress of sepsis.
Thirty-six male Sprague-Dawley rats were randomized into six groups, with cecal ligation and puncture (CLP) performed in all but the sham-control group.
Rats in CLP + BHT-L6 and CLP + BHT-H6 groups, respectively, received a low (0.45 g/kg) and high doses (0.9 g/kg) of BHT, 6 hrs postoperatively.
CLP + BHT-L12 and CLP + BHT-H12 groups, respectively, received low and high doses of BHT, 12 hrs postoperatively.
Sham-control and sepsis-control groups received distilled water (1 mL) as vehicle, 6 hrs postoperatively.
Serial blood samples were drawn before operation, as baseline, and at 4, 8, and 12 hrs postoperatively for IL-6 and IL-10 assay.
All rats were monitored for 3 days for survival study.
Rats in the CLP + BHT-H6 group had significantly higher survival rate (80%) and significantly lower levels of both IL-6 and IL-10 at 12 hrs postoperatively than those in the sepsis-control group.
Results suggested that BHT may be a new complementary treatment option for sepsis.
American Psychological Association (APA)
Lin, Chien-Jung& Su, Yi-Chang& Lee, Cheng-Hung& Li, Tsai-Chung& Chen, Yun-An& Lin, Sunny Jui-Shan. 2013. Bai-Hu-Tang, Ancient Chinese Medicine Formula, May Provide a New Complementary Treatment Option for Sepsis. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-453383
Modern Language Association (MLA)
Lin, Chien-Jung…[et al.]. Bai-Hu-Tang, Ancient Chinese Medicine Formula, May Provide a New Complementary Treatment Option for Sepsis. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-8.
https://search.emarefa.net/detail/BIM-453383
American Medical Association (AMA)
Lin, Chien-Jung& Su, Yi-Chang& Lee, Cheng-Hung& Li, Tsai-Chung& Chen, Yun-An& Lin, Sunny Jui-Shan. Bai-Hu-Tang, Ancient Chinese Medicine Formula, May Provide a New Complementary Treatment Option for Sepsis. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-8.
https://search.emarefa.net/detail/BIM-453383
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-453383