![](/images/graphics-bg.png)
Successful Treatment of Acute Lymphoblastic Leukemia in a Child with Trisomy 21 and Complex Congenital Heart Disease with Mechanical Prosthetic Valve
Joint Authors
Rassekh, Shahrad Rod
Alvi, Saima
Shereck, Evan
Sandor, George G. S.
Heran, Manraj K. S.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-02
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Abstract EN
A 10-year-old girl with trisomy 21 and complex congenital heart disease presented with acute lymphoblastic leukemia.
Her chemotherapy required modifications due to poor baseline cardiac status and a mechanical prosthetic heart valve that was dependent on anticoagulation.
We describe our management including the use of low-molecular-weight heparin as anticoagulation for a mechanical heart valve, the safe delivery of intrathecal chemotherapy included bridging with unfractionated heparin, and the use of fluoroscopic guidance to minimize the risk of bleeding.
Adjustments were made to avoid anthracyclines.
The child tolerated therapy well without complications and remains relapse free five years after diagnosis.
American Psychological Association (APA)
Alvi, Saima& Shereck, Evan& Heran, Manraj K. S.& Sandor, George G. S.& Rassekh, Shahrad Rod. 2012. Successful Treatment of Acute Lymphoblastic Leukemia in a Child with Trisomy 21 and Complex Congenital Heart Disease with Mechanical Prosthetic Valve. Case Reports in Pediatrics،Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-453387
Modern Language Association (MLA)
Alvi, Saima…[et al.]. Successful Treatment of Acute Lymphoblastic Leukemia in a Child with Trisomy 21 and Complex Congenital Heart Disease with Mechanical Prosthetic Valve. Case Reports in Pediatrics No. 2012 (2012), pp.1-4.
https://search.emarefa.net/detail/BIM-453387
American Medical Association (AMA)
Alvi, Saima& Shereck, Evan& Heran, Manraj K. S.& Sandor, George G. S.& Rassekh, Shahrad Rod. Successful Treatment of Acute Lymphoblastic Leukemia in a Child with Trisomy 21 and Complex Congenital Heart Disease with Mechanical Prosthetic Valve. Case Reports in Pediatrics. 2012. Vol. 2012, no. 2012, pp.1-4.
https://search.emarefa.net/detail/BIM-453387
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-453387