Molecular Aspects of H. pylori-Related MALT Lymphoma
Joint Authors
Smith, Lauren B.
Owens, Scott R.
Source
Pathology Research International
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-01-24
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Helicobacter pylori-related extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue is a paradigm for malignancy arising in an inflammatory background.
While the diagnosis of H.
pylori gastritis is often straightforward, distinction between severe gastritis and early lymphoma can be difficult and requires careful assessment of clinical findings in addition to histological features and immunohistochemical results.
A number of cytogenetic abnormalities have been discovered in H.
pylori-related lymphomas and several have clinical importance, related to the responsiveness of lymphoma to H.
pylori eradication therapy, but routine molecular studies are not widely utilized.
While molecular methods may be used in equivocal cases, a trial of conservative therapy is warranted given the propensity for these lymphomas to regress with eradication of the organism.
Once therapy is initiated, care must be taken to avoid a premature assignment of disease refractoriness because complete response can take several months to more than a year.
Cases truly refractory to H.
pylori eradication therapy may be treated with adjuvant chemoradiation with a high response rate.
American Psychological Association (APA)
Owens, Scott R.& Smith, Lauren B.. 2011. Molecular Aspects of H. pylori-Related MALT Lymphoma. Pathology Research International،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-453394
Modern Language Association (MLA)
Owens, Scott R.& Smith, Lauren B.. Molecular Aspects of H. pylori-Related MALT Lymphoma. Pathology Research International No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-453394
American Medical Association (AMA)
Owens, Scott R.& Smith, Lauren B.. Molecular Aspects of H. pylori-Related MALT Lymphoma. Pathology Research International. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-453394
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-453394