![](/images/graphics-bg.png)
Anticancer Drug-Incorporated Layered Double Hydroxide Nanohybrids and Their Enhanced Anticancer Therapeutic Efficacy in Combination Cancer Treatment
Joint Authors
Kim, Hyoung-Jun
Kim, Tae-il
Kang, Joo-Hee
Lee, Gyeong Jin
Kim, Tae-Hyun
Oh, Jae-Min
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-17
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Objective.
Layered double hydroxide (LDH) nanoparticles have been studied as cellular delivery carriers for anionic anticancer agents.
As MTX and 5-FU are clinically utilized anticancer drugs in combination therapy, we aimed to enhance the therapeutic performance with the help of LDH nanoparticles.
Method.
Anticancer drugs, MTX and 5-FU, and their combination, were incorporated into LDH by reconstruction method.
Simply, LDHs were thermally pretreated at 400°C, and then reacted with drug solution to simultaneously form drug-incorporated LDH.
Thus prepared MTX/LDH (ML), 5-FU/LDH (FL), and (MTX + 5-FU)/LDH (MFL) nanohybrids were characterized by X-ray diffractometer, scanning electron microscopy, infrared spectroscopy, thermal analysis, zeta potential measurement, dynamic light scattering, and so forth.
The nanohybrids were administrated to the human cervical adenocarcinoma, HeLa cells, in concentration-dependent manner, comparing with drug itself to verify the enhanced therapeutic efficacy.
Conclusion.
All the nanohybrids successfully accommodated intended drug molecules in their house-of-card-like structures during reconstruction reaction.
It was found that the anticancer efficacy of MFL nanohybrid was higher than other nanohybrids, free drugs, or their mixtures, which means the multidrug-incorporated LDH nanohybrids could be potential drug delivery carriers for efficient cancer treatment via combination therapy.
American Psychological Association (APA)
Kim, Tae-Hyun& Lee, Gyeong Jin& Kang, Joo-Hee& Kim, Hyoung-Jun& Kim, Tae-il& Oh, Jae-Min. 2014. Anticancer Drug-Incorporated Layered Double Hydroxide Nanohybrids and Their Enhanced Anticancer Therapeutic Efficacy in Combination Cancer Treatment. BioMed Research International،Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-453411
Modern Language Association (MLA)
Kim, Tae-Hyun…[et al.]. Anticancer Drug-Incorporated Layered Double Hydroxide Nanohybrids and Their Enhanced Anticancer Therapeutic Efficacy in Combination Cancer Treatment. BioMed Research International No. 2014 (2014), pp.1-11.
https://search.emarefa.net/detail/BIM-453411
American Medical Association (AMA)
Kim, Tae-Hyun& Lee, Gyeong Jin& Kang, Joo-Hee& Kim, Hyoung-Jun& Kim, Tae-il& Oh, Jae-Min. Anticancer Drug-Incorporated Layered Double Hydroxide Nanohybrids and Their Enhanced Anticancer Therapeutic Efficacy in Combination Cancer Treatment. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-11.
https://search.emarefa.net/detail/BIM-453411
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-453411