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Antiangiogenic Therapy for Patients with Recurrent and Newly Diagnosed Malignant Gliomas
Joint Authors
Chakravarti, Arnab
Shirai, Katsuyuki
Siedow, Michael R.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-07-14
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Malignant gliomas have a poor prognosis despite advances in diagnosis and therapy.
Although postoperative temozolomide and radiotherapy improve overall survival in glioblastoma patients, most patients experience a recurrence.
The prognosis of recurrent malignant gliomas is dismal, and more effective therapeutic strategies are clearly needed.
Antiangiogenesis is currently considered an attractive targeting therapy for malignant gliomas due to its important role in tumor growth.
Clinical trials using bevacizumab have been performed for recurrent glioblastoma, and these studies have shown promising response rates along with progression-free survival.
Based on the encouraging results, bevacizumab was approved by the FDA for the treatment of recurrent glioblastoma.
In addition, bevacizumab has shown to be effective for recurrent anaplastic gliomas.
Large phase III studies are currently ongoing to demonstrate the efficacy and safety of the addition of bevacizumab to temozolomide and radiotherapy for newly diagnosed glioblastoma.
In contrast, several other antiangiogenic drugs have also been used in clinical trials.
However, previous studies have not shown whether antiangiogenesis improves the overall survival of malignant gliomas.
Specific severe side effects, difficult assessment of response, and lack of rational predictive markers are challenging problems.
Further studies are warranted to establish the optimized antiangiogenesis therapy for malignant gliomas.
American Psychological Association (APA)
Shirai, Katsuyuki& Siedow, Michael R.& Chakravarti, Arnab. 2011. Antiangiogenic Therapy for Patients with Recurrent and Newly Diagnosed Malignant Gliomas. Journal of Oncology،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-453415
Modern Language Association (MLA)
Shirai, Katsuyuki…[et al.]. Antiangiogenic Therapy for Patients with Recurrent and Newly Diagnosed Malignant Gliomas. Journal of Oncology No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-453415
American Medical Association (AMA)
Shirai, Katsuyuki& Siedow, Michael R.& Chakravarti, Arnab. Antiangiogenic Therapy for Patients with Recurrent and Newly Diagnosed Malignant Gliomas. Journal of Oncology. 2011. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-453415
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-453415